Cilia-driven flows in the brain third ventricle
| Autor: | Ann-Kathrin Günther, Eberhard Bodenschatz, Shoba Kapoor, Christian Westendorf, Zuzana Ditte, Yong Wang, Gregor Eichele |
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| Rok vydání: | 2019 |
| Předmět: |
Hypothalamus
translational polarity Review Article fluid dynamics Biology cerebrospinal fluid General Biochemistry Genetics and Molecular Biology Cerebrospinal fluid medicine Cilia Third Ventricle Brain Ventricle Third ventricle Tanycyte Cilium Biological Transport Articles tanycyte medicine.anatomical_structure Ventricle Motile cilium Choroid plexus extracellular vesicles General Agricultural and Biological Sciences Neuroscience |
| Zdroj: | Philosophical Transactions of the Royal Society B: Biological Sciences |
| ISSN: | 1471-2970 0962-8436 |
| DOI: | 10.1098/rstb.2019.0154 |
| Popis: | The brain ventricles are interconnected, elaborate cavities that traverse the brain. They are filled with cerebrospinal fluid (CSF) that is, to a large part, produced by the choroid plexus, a secretory epithelium that reaches into the ventricles. CSF is rich in cytokines, growth factors and extracellular vesicles that glide along the walls of ventricles, powered by bundles of motile cilia that coat the ventricular wall. We review the cellular and biochemical properties of the ventral part of the third ventricle that is surrounded by the hypothalamus. In particular, we consider the recently discovered intricate network of cilia-driven flows that characterize this ventricle and discuss the potential physiological significance of this flow for the directional transport of CSF signals to cellular targets located either within the third ventricle or in the adjacent hypothalamic brain parenchyma. Cilia-driven streams of signalling molecules offer an exciting perspective on how fluid-borne signals are dynamically transmitted in the brain. This article is part of the Theo Murphy meeting issue ‘Unity and diversity of cilia in locomotion and transport’. |
| Databáze: | OpenAIRE |
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