The role of pulmonary metastasectomy for hepatoblastoma in children with metastasis at diagnosis: Results from the JPLT-2 study
| Autor: | Osamu Miyazaki, Tetsuya Takimoto, Kohmei Ida, Junya Fujimura, Yuichi Takama, Hiroshi Fuji, Ken Hoshino, Tomoro Hishiki, Makiko Mori, Tomoaki Taguchi, Eiso Hiyama, Michihiro Yano, Takuro Kazama, Yuki Aoki, Kenichi Yoshimura, Tomoko Iehara, Akiko Yokoi, Shohei Honda, Kenichiro Watanabe, Kimikazu Matsumoto, Kentaro Kihira, Yukichi Tanaka |
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| Rok vydání: | 2017 |
| Předmět: |
Hepatoblastoma
medicine.medical_specialty Lung Neoplasms Liver tumor medicine.medical_treatment Disease-Free Survival Metastasis 03 medical and health sciences 0302 clinical medicine medicine Hepatectomy Humans Prospective Studies Thoracotomy Child Prospective cohort study Lung business.industry Liver Neoplasms Metastasectomy Induction chemotherapy Induction Chemotherapy General Medicine medicine.disease Surgery Treatment Outcome medicine.anatomical_structure 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health 030211 gastroenterology & hepatology business |
| Zdroj: | Journal of Pediatric Surgery. 52:2051-2055 |
| ISSN: | 0022-3468 |
| DOI: | 10.1016/j.jpedsurg.2017.08.031 |
| Popis: | Background/purpose The purpose of this study was to clarify the role of pulmonary metastasectomy in hepatoblastomas with lung metastasis at diagnosis. We reviewed cases enrolled in the JPLT-2 study. Methods A total of 360 cases with hepatoblastoma were enrolled. The clinical courses and outcome of 60 cases with pulmonary metastasis at diagnosis were reviewed, focusing on metastasectomy. Results Induction chemotherapy resulted in eradication of nodules in 26, residual nodules in 33, and early treatment-related death in one. Of the 33 cases with residual nodules, 11 underwent complete resection of the lung lesions, and among these, progression was reported in five. Complete resection of the liver tumor was not achieved in two of these. Three underwent incomplete resection of lung nodules, eventually leading to progression. Twelve cases with incomplete or no liver tumor resection progressed regardless of the status of lung lesions. Contrarily, among patients who underwent complete resection of the liver tumor, half were cured without metastasectomy. Conclusions Metastasectomy for residual pulmonary nodules after induction chemotherapy is effective provided that the liver tumor could be completely resected. Type of study Prospective Cohort Study. Level of evidence Level II. |
| Databáze: | OpenAIRE |
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