Induction or consolidation chemotherapy for unresectable stage III non-small-cell lung cancer patients treated with concurrent chemoradiation: a randomised phase II trial GFPC - IFCT 02-01
| Autor: | L. Gérinière, Jean-Pierre Daurès, G. Robinet, E. Jonveaux, S. Bota, R. Gervais, Hervé Le Caer, J. Mandet, L. Falchero, L. Thiberville, J. Créquit, S. Ramdane, R. Poirier, D. Coetmeur, B. Lamezec, G.M. Jung, S. Schouabe, O. Gallocher, P. Clavére, P. Fournel, E. Touboul, A. Vergnenégre, A. D'Hombres, B. Kin, F. Mornex, Christos Chouaid, Pierre-Jean Souquet, F. Blanchon, Marie-Cécile Bozonnat, J.N. Talabard, A. Rivière, Isabelle Martel-Lafay, B. Mennecier, M. Perol, P.J. Souquet, A. Lavolé, S. Bayle, F. Barlesi, T. Pignon, Pierre Fournel, H. Le Caer, J.P. Labat, A. Vergnenegre, E. Tessier, C. Gimenez, H. Léna, P. Thomas, P. Barre, G. Zalcman, D. Perdu, Y. Coscas, J.C. Pietra, P. Martin, D. Lerouge, D. Herman, J.Y. Delhoume, J. M. Chavaillon, B. Melloni, J.M. Chavaillon, R. Trouette, M. Benchalal, D. Arpin, C. Decroisette, B. Milleron, I. Martel-Lafay, A. Cauchois, H. Ramos, A. Roquette, J. Letreut, H. Berard, D. Paillotin, A. Ducolone, J.M. Vernejoux, P. Verrelle, J.C. Bout, J.P. Suchaud, H. Janicot, Radj Gervais, A. Zribi, A. Benyoub, V. Grangeon, Gilles Robinet, C. Bonnamour, M. Grivaux, C. Chouaid, E. Quoix, C. Belleguic, P. Merle, E. Dansin, M.A. Zawadi, Hervé Lena, J.B. Auliac |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Oncology Adult Male Cancer Research medicine.medical_specialty Lung Neoplasms Time Factors Paclitaxel medicine.medical_treatment Phases of clinical research Vinorelbine Vinblastine Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Carcinoma Non-Small-Cell Lung Antineoplastic Combined Chemotherapy Protocols medicine Humans Lung cancer Aged Neoplasm Staging Cisplatin Chemotherapy business.industry Induction chemotherapy Consolidation Chemotherapy Radiotherapy Dosage Chemoradiotherapy Induction Chemotherapy Middle Aged medicine.disease Survival Analysis 030104 developmental biology Treatment Outcome 030220 oncology & carcinogenesis Female business medicine.drug |
| Zdroj: | European journal of cancer (Oxford, England : 1990). 52 |
| ISSN: | 1879-0852 |
| Popis: | Purpose The objective of this randomised phase II study was to evaluate the impact in terms of response and toxicities of induction or consolidation chemotherapy respectively before or after concurrent chemoradiotherapy in unresectable stage III non-small-cell lung cancer. Patients and methods In the induction arm, patients received induction chemotherapy with cisplatin (80 mg/m 2 ) and paclitaxel (200 mg/m 2 ) on days 1 and 29 followed by a concurrent chemoradiotherapy (66 Gy in 33 fractions, cisplatin 80 mg/m 2 days 1, 29 and 57, vinorelbine 15 mg/m 2 days 1, 8, 29, 36, 57 and 64). In consolidation arm, the same concurrent chemoradiotherapy began on day 1 followed by two cycles of cisplatin and paclitaxel. Results One hundred twenty seven patients were randomised. The intent to treat response rates in induction and consolidation arms were 58% and 56% respectively. Median survival was 19.6 months in induction arm and 16.3 months in consolidation arm and 4-year survival rates were 21% and 30% respectively. Haematologic and non-haematologic toxicities were similar in both arms, except grade 3/4 oesophagitis, more frequent in consolidation arm than in induction arm (17% versus 10%). Conclusion Cisplatin-based chemotherapy as induction or consolidation with concurrent chemoradiotherapy can be administrated safely. Response rates were similar in both arms with a trend in favour for consolidation arm for long-term survival. |
| Databáze: | OpenAIRE |
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