Multifunctional coatings to simultaneously promote osseointegration and prevent infection of orthopaedic implants
| Autor: | Sarah C. Heilshorn, Stuart B. Goodman, Mark Holodniy, Jordan Raphel |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Prosthesis-Related Infections
Joint arthroplasty Joint replacement Joint Prosthesis medicine.medical_treatment Biophysics Aseptic loosening Dentistry Periprosthetic Bioengineering 02 engineering and technology 010402 general chemistry 01 natural sciences Article Osseointegration Biomaterials Coated Materials Biocompatible Animals Humans Medicine Bacteria business.industry 021001 nanoscience & nanotechnology Prosthesis Failure 0104 chemical sciences Mechanics of Materials Ceramics and Composites Implant 0210 nano-technology business Microbial Susceptibility |
| Zdroj: | Biomaterials. 84:301-314 |
| ISSN: | 0142-9612 |
| DOI: | 10.1016/j.biomaterials.2016.01.016 |
| Popis: | The two leading causes of failure for joint arthroplasty prostheses are aseptic loosening and periprosthetic joint infection. With the number of primary and revision joint replacement surgeries on the rise, strategies to mitigate these failure modes have become increasingly important. Much of the recent work in this field has focused on the design of coatings either to prevent infection while ignoring bone mineralization or vice versa, to promote osseointegration while ignoring microbial susceptibility. However, both coating functions are required to achieve long-term success of the implant; therefore, these two modalities must be evaluated in parallel during the development of new orthopaedic coating strategies. In this review, we discuss recent progress and future directions for the design of multifunctional orthopaedic coatings that can inhibit microbial cells while still promoting osseointegration. |
| Databáze: | OpenAIRE |
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