The Utility of ERBB4 and RB1 Immunohistochemistry in Distinguishing Chromophobe Renal Cell Carcinoma From Renal Oncocytoma
| Autor: | Karen Dresser, Nicole Ninteau, Qingqing Liu, Lloyd Hutchinson, Tong Sun, Liang Cheng, Zhong Jiang, Ediz F. Cosar, Maryann St. Cyr, Amy G. Zhou, Kristine M. Cornejo |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Receptor ErbB-4 Ubiquitin-Protein Ligases Chromophobe Renal Cell Carcinoma Biology Pathology and Forensic Medicine Diagnosis Differential 03 medical and health sciences 0302 clinical medicine medicine Biomarkers Tumor Adenoma Oxyphilic Humans Copy-number variation Renal oncocytoma Carcinoma Renal Cell ERBB4 Kidney medicine.diagnostic_test medicine.disease Immunohistochemistry eye diseases Kidney Neoplasms Staining Retinoblastoma Binding Proteins 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Surgery Anatomy Fluorescence in situ hybridization |
| Zdroj: | International journal of surgical pathology. 28(3) |
| ISSN: | 1940-2465 |
| Popis: | Objectives. Differentiating renal oncocytoma (RO) from chromophobe renal cell carcinoma (ChRCC) can occasionally be challenging. We evaluated the expression of RB1 and ERBB4 in RO and ChRCC, and compared the immunohistochemistry (IHC) results to RB1 and ERBB4 gene abnormalities detected by fluorescence in situ hybridization (FISH). Materials and Methods. Fifty-three kidney resections (ChRCC, n=28; RO, n=25) were stained for RB1 and ERBB4 IHC and FISH was performed to evaluate gene copy number analysis. Results. A loss of RB1 staining was identified in 64% (18/28) of ChRCCs, which was not found in any ROs (0/25; P |
| Databáze: | OpenAIRE |
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