Chinese Medicine Amygdalin and β-Glucosidase Combined with Antibody Enzymatic Prodrug System As A Feasible Antitumor Therapy
| Autor: | Yun-long Li, Xiang-qian Shen, Qiao-xing Li, Rui-jiang Liu |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
medicine.drug_class Amygdalin Antineoplastic Agents Cell-Penetrating Peptides Pharmacology Monoclonal antibody 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Antigen medicine Humans Iridoids Prodrugs Pharmacology (medical) chemistry.chemical_classification biology business.industry beta-Glucosidase Antibodies Monoclonal General Medicine Amarogentin Prodrug 030104 developmental biology Enzyme Complementary and alternative medicine chemistry Biochemistry 030220 oncology & carcinogenesis Cancer cell biology.protein Antibody business Adenosine triphosphate |
| Zdroj: | Chinese Journal of Integrative Medicine. 24:237-240 |
| ISSN: | 1993-0402 1672-0415 |
| Popis: | Amarogentin is an efficacious Chinese herbal medicine and a component of the bitter apricot kernel. It is commonly used as an expectorant and supplementary anti-cancer drug. β-Glucosidase is an enzyme that hydrolyzes the glycosidic bond between aryl and saccharide groups to release glucose. Upon their interaction, β-glucosidase catalyzes amarogentin to produce considerable amounts of hydrocyanic acid, which inhibits cytochrome C oxidase, the terminal enzyme in the mitochondrial respiration chain, and suspends adenosine triphosphate synthesis, resulting in cell death. Hydrocyanic acid is a cell-cycle-stage-nonspecific agent that kills cancer cells. Thus, β-glucosidase can be coupled with a tumor-specific monoclonal antibody. β-Glucosidase can combine with cancer-cell-surface antigens and specifically convert amarogentin to an active drug that acts on cancer cells and the surrounding antibodies to achieve a killing effect. β-Glucosidase is injected intravenously and recognizes cancer-cell-surface antigens with the help of an antibody. The prodrug amarogentin is infused after β-glucosidase has reached the target position. Coupling of cell membrane peptides with β-glucosidase allows the enzyme to penetrate capillary endothelial cells and clear extracellular deep solid tumors to kill the cells therein. The Chinese medicine amarogentin and β-glucosidase will become an important treatment for various tumors when an appropriate monoclonal antibody is developed. |
| Databáze: | OpenAIRE |
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