Development, organization and plasticity of auditory circuits: Lessons from a cherished colleague
Autor: | Victoria M. Bajo, Andrew J. King, Michael Lohse |
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Rok vydání: | 2018 |
Předmět: |
Sound localization
corticothalamic Auditory Pathways Sensory processing Computer science medicine.medical_treatment media_common.quotation_subject Thalamus midbrain Sensory system Visual system History 21st Century 03 medical and health sciences 0302 clinical medicine Perception medicine Biological neural network Animals Auditory system Sound Localization Ray Guillery Special Issue ferret 030304 developmental biology media_common Auditory Cortex 0303 health sciences Neuronal Plasticity General Neuroscience Ferrets Neurosciences History 20th Century Special Issue Review cortex medicine.anatomical_structure Auditory Perception corticocollicular Neuroscience 030217 neurology & neurosurgery |
Zdroj: | The European Journal of Neuroscience |
ISSN: | 0953-816X |
Popis: | Ray Guillery was a neuroscientist known primarily for his ground‐breaking studies on the development of the visual pathways and subsequently on the nature of thalamocortical processing loops. The legacy of his work, however, extends well beyond the visual system. Thanks to Ray Guillery's pioneering anatomical studies, the ferret has become a widely used animal model for investigating the development and plasticity of sensory processing. This includes our own work on the auditory system, where experiments in ferrets have revealed the role of sensory experience during development in shaping the neural circuits responsible for sound localization, as well as the capacity of the mature brain to adapt to changes in inputs resulting from hearing loss. Our research has also built on Ray Guillery's ideas about the possible functions of the massive descending projections that link sensory areas of the cerebral cortex to the thalamus and other subcortical targets, by demonstrating a role for corticothalamic feedback in the perception of complex sounds and for corticollicular projection neurons in learning to accommodate altered auditory spatial cues. Finally, his insights into the organization and functions of transthalamic corticocortical connections have inspired a raft of research, including by our own laboratory, which has attempted to identify how information flows through the thalamus. |
Databáze: | OpenAIRE |
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