Cardiovascular risk factors and frailty in a cross-sectional study of older people: implications for prevention

Autor: Rose Anne Kenny, T Y Wong, Aisling M O'Halloran, M S Massa, Robert Clarke
Rok vydání: 2018
Předmět:
Male
cardiovascular risk factors
Gerontology
Aging
Longitudinal study
Cross-sectional study
Cost-Benefit Analysis
Frail Elderly
General Practice
frailty
030204 cardiovascular system & hematology
Logistic regression
Risk Assessment
older people
03 medical and health sciences
0302 clinical medicine
prevention
Quality of life
Risk Factors
Activities of Daily Living
Humans
Medicine
cardiovascular diseases
030212 general & internal medicine
Social Behavior
Aged
Netherlands
Aged
80 and over
Primary Health Care
Delivery of Health Care
Integrated
business.industry
Age Factors
Health Care Costs
General Medicine
Odds ratio
Prognosis
Confidence interval
Cross-Sectional Studies
Cardiovascular Diseases
Meta-analysis
Quality of Life
Female
Controlled Clinical Trials as Topic
Geriatrics and Gerontology
Risk assessment
business
Research Paper
Zdroj: Age and Ageing
ISSN: 1468-2834
0002-0729
DOI: 10.1093/ageing/afy080
Popis: Objective to examine the associations of cardiovascular disease (CVD) and cardiovascular risk factors with frailty. Design a cross-sectional study. Setting the Irish Longitudinal Study on Ageing (TILDA). Participants frailty measures were obtained on 5,618 participants and a subset of 4,330 participants with no prior history of CVD. Exposures for observational study cardiovascular risk factors were combined in three composite CVD risk scores (Systematic Coronary Risk Evaluation [SCORE], Ideal Cardiovascular Health [ICH] and Cardiovascular Health Metrics [CHM]). Main outcome measures a frailty index (40-items) was used to screen for frailty. Methods the associations of CVD risk factors with frailty were examined using logistic regression. Results overall, 16.4% of participants had frailty (7.6% at 50–59 years to 42.5% at 80+ years), and the prevalence was higher in those with versus those without prior CVD (43.0% vs. 10.7%). Among those without prior CVD, mean levels of CVD risk factors were closely correlated with higher frailty index scores. Combined CVD risk factors, assessed using SCORE, were linearly and positively associated with frailty. Compared to low-to-moderate SCOREs, the odds ratio (OR) (95% confidence interval, CI) of frailty for those with very high risk was 3.18 (2.38–4.25). Conversely, ICH was linearly and inversely associated with frailty, with an OR for optimal health of 0.29 (0.21–0.40) compared with inadequate health. Conclusions the concordant positive associations of SCORE and inverse associations of ICH and CHM with frailty highlight the potential importance of optimum levels of CVD risk factors for prevention of disability in frail older people.
Databáze: OpenAIRE
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