Platelet Activity in Migraine
| Autor: | Giovanni D' Andrea, Moreno Toldo, S Cortelazzo, Francesco Ferro Milone |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Adult
Blood Platelets Serotonin medicine.medical_specialty Migraine Disorders Platelet Factor 4 Basal (phylogenetics) In vivo Internal medicine medicine Humans Platelet Platelet activation 5-HT receptor business.industry Plasma levels Middle Aged beta-Thromboglobulin medicine.disease Endocrinology Neurology Migraine Anesthesia Female Neurology (clinical) business |
| Zdroj: | Headache: The Journal of Head and Face Pain. 22:207-212 |
| ISSN: | 1526-4610 0017-8748 |
| DOI: | 10.1111/j.1526-4610.1982.hed2205207.x |
| Popis: | SYNOPSIS Migraine is a disease associated with increased platelet activity. The aim of this paper was to study "in vivo" platelet activation by assessing platelet serotonin (5HT) content and beta-thromboglobulin (B-TG) and platelet factor four (PF4) plasma levels, in headache-free-periods and during migraine attacks. In headache-free-periods, there was no differences in platelet 5HT values between migraine patients and control subjects. On the other hand, there were significant differences in B-TG and PF4 plasma levels. Furthermore, two groups of migraine patients were observed, one with normal B-TG plasma levels and the other with high B-TG plasma levels. PF4 plasma levels behave similarly. During migraine attacks, platelet 5-HT fell, while B-TG and PF4 plasma levels rose, if compared to the values recorded immediately before attacks. We suggest that migraine patients, particularly those ones with high basal values of B-TG and PF4 plasma levels, form a high risk group to cerebrovascular ischaemic diseases. For these patients a prophylaxis with antiplatelet drugs is indicated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text