Association between extent of resection on survival in adult brainstem high-grade glioma patients
| Autor: | Yi Sun, Joshua Doyle, Debraj Mukherjee, Wuyang Yang, Chetan Bettegowda, Adham M. Khalafallah |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Neurology medicine.medical_treatment Extent of resection Neurosurgical Procedures 03 medical and health sciences 0302 clinical medicine Biopsy Medicine Brain Stem Neoplasms Humans High-Grade Glioma medicine.diagnostic_test Proportional hazards model business.industry Glioma Middle Aged Surgery Radiation therapy Treatment Outcome Oncology 030220 oncology & carcinogenesis Cohort Female Neurology (clinical) Brainstem business 030217 neurology & neurosurgery SEER Program |
| Zdroj: | Journal of neuro-oncology. 145(3) |
| ISSN: | 1573-7373 |
| Popis: | Brainstem high-grade gliomas (HGG) are rare lesions with aggressive behavior that pose significant treatment challenges. The operative use of brainstem safe entry zones has made such lesions surgically accessible, though the benefits of aggressive resection have been unclear. This study aimed to clarify the survival in adult patients. We utilized the SEER database (1973–2015) to analyze the association between survival and demographic data, tumor characteristics, and treatment factors in adult patients with brainstem HGGs. Patients without surgical intervention were excluded. Overall survival (OS) was analyzed using univariable and multivariable Cox regression. Our dataset included a total of 502 brainstem HGG patients of which only those who had undergone surgical intervention were included in the analysis, totaling 103. Mean age was 42.4 ± 14.1 years with 57.2% (n = 59) male. Median OS of the entire cohort was 11.0 months. Median OS for patients receiving biopsy, subtotal resection, and gross total resection were 8, 11, and 16 months, respectively. Age, extent of resection, and radiation therapy were selected into the multivariable model. A significant decrease in survival was seen in older patients, 50–60 years (HR = 2.77, p = 0.002) and ≥ 60 years (HR = 5.30, p |
| Databáze: | OpenAIRE |
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