Acrylate-gelatin–carbonated hydroxyapatite(cHAP) composites for dental bone-tissue applications
| Autor: | Aleksej Zarkov, Zivile Stankeviciute, Lars Hansson, Raimundas Golubevas, Rimantas Raudonis, Aivaras Kareiva, Ricardas Golubevas, Edita Garskaite |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
food.ingredient
Materials science Biocompatibility Ethylene glycol dimethacrylate Composite number 02 engineering and technology 010402 general chemistry Bone tissue 01 natural sciences Gelatin Crystallinity chemistry.chemical_compound food medicine carbonated hydroxyapatite composites dental bone-tissue scaffolds General Materials Science Wood Science Composite material chemistry.chemical_classification Acrylate Polymer 021001 nanoscience & nanotechnology 0104 chemical sciences medicine.anatomical_structure chemistry Chemistry (miscellaneous) Trävetenskap 0210 nano-technology |
| Zdroj: | Materials advances, London : The Royal Society of Chemistry, 2020, vol. 1, no. 6, p. 1675-1684 |
| ISSN: | 2633-5409 |
| Popis: | Various types of scaffolds made of synthetic polymers have been widely studied for bone-tissue applications due to their mechanical strength, biocompatibility and biodegradability, but the hydrophobic nature of synthetic polymers and frequent absence of pores within the scaffolds inhibit cellular attachment, infiltration, and tissue ingrowth. In this study, multi-composite scaffolds composed of dipentaerythritol hexa-acrylate (DPHA), ethylene glycol dimethacrylate (EGDMA), gelatin, and carbonated hydroxyapatite (cHAP) have been made. Percentage ratio of polymer matrix to gelatin was varied 50/50, 75/25, and 95/5 to change the porosity of the resultant scaffolds. The structure, crystallinity, and phase composition of the cHAP were confirmed by FTIR, Raman, XRD and Rietveld analyses, TG/DSC was used to evaluate the distribution of ceramics within the polymer matrix, and FTIR-ATR was used to confirm the molecular structure of composites. SEM/EDS analysis of the scaffolds revealed cavities and irregularities in the surface, and that cHAP was indistinctly exposed on the composite surface, computed tomography (CT) was used to estimate the density and homogeneity of the scaffolds, and the cHAP distribution within the scaffolds was evaluated by conventional radiography. The hydrophilicity of the multi-composite scaffolds was investigated using an aqueous solution of methylene blue dye which showed that the acrylate(75%)–gelatin(25%)–cHAP composite had the highest hydrophilicity. The results suggest that acrylate–gelatin–cHAP scaffolds have a potential for bone-tissue engineering. Godkänd;2021;Nivå 0;2021-02-09 (johcin) FORMAS "Utilization of solid inorganic waste from the aquaculture industry as wood reinforcement material for flame retardancy 2018-01198" |
| Databáze: | OpenAIRE |
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