Effect of repeated oral infection of hamsters with scrapie

Autor:	Michael Beekes, Heino Diringer, Joachim Roehmel
Rok vydání:	1998
Předmět:	Infectivity Transmissible spongiform encephalopathy Oral infection Incidence (epidemiology) Repeated dosing Administration Oral Scrapie Biology medicine.disease Virology Drug Administration Schedule Injections Cricetinae Immunology medicine Animals Dosing Infectious agent
Zdroj:	Journal of General Virology. 79:609-612
ISSN:	1465-2099 0022-1317
DOI:	10.1099/0022-1317-79-3-609
Popis:	The development of a transmissible spongiform encephalopathy upon uptake of the infectious agent in feed was studied in the model system scrapie in hamsters. Compared to single dosing, repeated dosing caused disease at a considerable higher incidence. The risk of infection was higher when the time interval between repetitive dosing was short. There was a statistically significant trend of clearance of infectivity with time.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::486eae1a5e84928049ec0120e620fc98 https://doi.org/10.1099/0022-1317-79-3-609 Zobrazit plný text záznamu