FSTL3 is increased in renal dysfunction
| Autor: | Susan Kralisch, Ingolf Bast, Michael Stumvoll, Thomas Ebert, Jürgen Kratzsch, Annett Hoffmann, Ming-Zhi Zhang, Anja Dietel, Joachim Beige, Matthias Anders, Jens-Uwe Stolzenburg, Raymond C. Harris, Matthias Blüher, Mathias Fasshauer, Nora Klöting, Anette Bachmann |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Follistatin-Related Proteins medicine.medical_treatment Renal function Gene Expression 030209 endocrinology & metabolism Myostatin urologic and male genital diseases Kidney 03 medical and health sciences Mice 0302 clinical medicine Downregulation and upregulation Internal medicine Medicine Animals Humans Renal Insufficiency Chronic Cells Cultured Aged Aged 80 and over Mice Knockout Transplantation Messenger RNA biology business.industry Insulin sensitivity Middle Aged medicine.disease Up-Regulation Mice Inbred C57BL 030104 developmental biology Endocrinology Cytokine Cross-Sectional Studies Liver Nephrology Case-Control Studies biology.protein Female Insulin Resistance business Kidney disease Follistatin Glomerular Filtration Rate |
| Zdroj: | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 32(10) |
| ISSN: | 1460-2385 |
| Popis: | Background Follistatin-like 3 (FSTL3) is a novel cytokine that regulates insulin sensitivity and counteracts activin/myostatin signalling. In the present study, regulation of FSTL3 in renal dysfunction was investigated in both human chronic kidney disease (CKD) and acute kidney dysfunction (AKD). Furthermore, mFSTL3 expression was analysed in insulin-sensitive tissues in a mouse model of CKD. Methods Circulating FSTL3 was quantified by enzyme-linked immunosorbent assay in 581 patients with CKD covering the whole spectrum of estimated glomerular filtration rate (eGFR) categories from G1 to G5. Furthermore, FSTL3 was measured in 61 patients before and within 30 h after elective unilateral nephrectomy, an established model of AKD. Moreover, mFSTL3 mRNA expression was investigated in an animal CKD model, that is, eNOS-/-db/db mice, and compared with littermate controls. Results Median circulating FSTL3 levels significantly and continuously increased with deteriorating renal function (eGFR category G1: 6.1; G2: 8.2; G3: 12.7; G4: 18.5; G5: 32.1 µg/L; P |
| Databáze: | OpenAIRE |
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