Measurement of interleukin-6 in bronchoalveolar lavage fluid by radioimmunoassay: differences between patients with interstitial lung disease and control subjects
| Autor: | B. H. Davies, J. H. Edwards, S. P. Reynolds, S. J. Capper, S. Kalinka, K. P. Jones |
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| Rok vydání: | 1991 |
| Předmět: |
Lung Diseases
Male Sarcoidosis Pulmonary Fibrosis Immunology Radioimmunoassay behavioral disciplines and activities Asymptomatic Idiopathic pulmonary fibrosis Bird Fancier's Lung Albumins medicine Humans Urea Immunology and Allergy Lung medicine.diagnostic_test Interleukin-6 business.industry Respiratory disease Interstitial lung disease Reference Standards medicine.disease medicine.anatomical_structure Bronchoalveolar lavage Immunoglobulin G Female medicine.symptom business Bronchoalveolar Lavage Fluid Research Article |
| Zdroj: | Clinical and Experimental Immunology. 83:30-34 |
| ISSN: | 1365-2249 0009-9104 |
| Popis: | SUMMARYBronchoalveolar lavage fluid (BALF) from subjects with a variety of interstitial lung diseases (active sarcoidosis, pigeon breeders' disease (PBD), asymptomatic pigeon breeders, patients with idiopathic pulmonary fibrosis) and from control subjects were assayed for interleukin-6 (IL-6) using a novel radioimmunoassay system. IL-6 was detectable in BALF from all groups, with disease groups showing significantly increased IL-6 levels compared with controls (P < 0.01 in all cases). When these results were standardized, using urea to compensate for dilution effects in the BALF, only the asymptomatic pigeon breeders had significantly higher IL-6 levels than the controls (P < 0.025), with all other groups showing no difference. When albumin was used for standardization, both the PBD group (P < 0.001) and the sarcoidosis patients (P < 0.01) had considerably lower levels of IL-6 than the control subjects. Using either albumin or urea for standardization, the PBD patients had significantly lower levels of IL-6 than do their asymptomatic counterparts (P < 0.001 in both cases). This is contrasted by the finding of greatly elevated levels of IgG in the BALF of the PBD patients compared with asymptomatics (P < 0.001). There was, however, no relation between IL-6 and IgG in any patient group, although the PBD patients had the lowest IL-6 and highest IgG as a group. These findings may suggest a mechanism by which asymptomatic subjects remain free from clinical complaints. |
| Databáze: | OpenAIRE |
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