Effectiveness of the once-daily calcium antagonist, lacidipine, in controlling 24-hour ambulatory blood pressure
| Autor: | Edward B. Raftery, Paul Broadhurst, G. Brigden, M E Heber |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Tachycardia
Male medicine.medical_specialty Dihydropyridines Ambulatory blood pressure chemistry.chemical_element Blood Pressure Calcium Drug Administration Schedule Heart Rate Internal medicine medicine Humans business.industry Antagonist Dihydropyridine Blood Pressure Determination Middle Aged Calcium Channel Blockers Blood Pressure Monitors Blood pressure Lacidipine chemistry Anesthesia Ambulatory Hypertension Cardiology Exercise Test Female medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | The American journal of cardiology. 66(17) |
| ISSN: | 0002-9149 |
| Popis: | The efficacy of the new once-daily dihydropyridine calcium antagonist, lacidipine, in reducing ambulatory intraarterial blood pressure (BP) was examined in 12 untreated hypertensive patients. The intraarterial recording was commenced 24 hours before the first 4-mg dose and was continued for a further 24 hours thereafter. After dose titration and chronic therapy, a second 24-hour ambulatory BP recording was made. There was a steady onset of drug action, maximal at 2 hours, but with reflex tachycardia after the first dose. Chronic administration reduced BP throughout the 24-hour period, without tachycardia. Mean daytime reduction in BP was 20 mm Hg systolic (p less than 0.005) and 12 mm Hg diastolic (p less than 0.02). Mean nighttime reduction was 8-mm Hg systolic (p less than 0.05) and 6-mm Hg diastolic (difference not significant). There was no postural decrease in BP on 60 degrees head-up tilting and hypotensive action was maintained during isometric exercise (reduction at peak of 32/18 mm Hg, p less than 0.05) and throughout dynamic exercise (reduction at peak of 23/14 mm Hg, p less than 0.05). Lacidipine is an effective once-daily antihypertensive agent, with good control of stress response. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|