Signalling circuits that direct early B-cell development
| Autor: | Georg Petkau, Martin R Turner |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
MAPK/ERK pathway
Lineage (genetic) MAP Kinase Signaling System Receptors Antigen B-Cell Apoptosis Biology Immunoglobulin light chain Biochemistry 03 medical and health sciences 0302 clinical medicine medicine Animals Humans Progenitor cell Gene Rearrangement B-Lymphocyte Molecular Biology PI3K/AKT/mTOR pathway B cell Cell Proliferation 030304 developmental biology B-Lymphocytes 0303 health sciences Genes Immunoglobulin Interleukin Cell Biology Cell biology medicine.anatomical_structure Immunoglobulin heavy chain 030215 immunology |
| Zdroj: | Biochemical Journal. 476:769-778 |
| ISSN: | 1470-8728 0264-6021 |
| DOI: | 10.1042/bcj20180565 |
| Popis: | In mammals, the B-cell lineage arises from pluripotent progenitors in the bone marrow. During their development, B-cells undergo lineage specification and commitment, followed by expansion and selection. These processes are mediated by regulated changes in gene expression programmes, rearrangements of immunoglobulin (Ig) genes, and well-timed rounds of proliferation and apoptosis. Many of these processes are initiated by environmental factors including cytokines, chemokines, and cell–cell contacts. Developing B-cells process these environmental cues into stage-specific functions via signalling pathways including the PI3K, MAPK, or JAK-STAT pathway. The cytokines FLT3-Ligand and c-Kit-Ligand are important for the early expansion of the B-cell precursors at different developmental stages and conditions. Interleukin 7 is essential for commitment to the B-cell lineage and for orchestrating the Ig recombination machinery. After rearrangement of the immunoglobulin heavy chain, proliferation and apoptosis, and thus selection, are mediated by the clonal pre-B-cell receptor, and, following light chain rearrangement, by the B-cell receptor. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|