β-Bungarotoxin inhibition of calcium accumulation by rat brain mitochondria

Autor: Regis B. Kelly, Gail M. Wagner, Patricia E. Mart
Rok vydání: 1974
Předmět:
Zdroj: Biochemical and Biophysical Research Communications. 58:475-481
ISSN: 0006-291X
DOI: 10.1016/0006-291x(74)90389-1
Popis: Electrophysiological studies have shown that β-bungarotoxin modifies the release of neurotransmitter from mammal ian motor-nerve terminals. In this paper we demonstrate that β-bungarotoxin can also inhibit calcium accumulation into sub-cellular fractions from rat brain at very low concentrations (2–8 pmoles toxin/mg protein). Since the calcium uptake which is inhibited has the characteristics of mitochondrial calcium accumulation (DNP-sensitivity, succinate stimulation), we conclude that the toxin affects the mitochondria. We suggest that the electrophysiological observations are consistent with direct or indirect inhibition by toxin of mitochondrial calcium uptake.
Databáze: OpenAIRE