Plasma concentrations of antipsychotics and QTc prolongation:a pilot study
| Autor: | Ljubica Vukelic Andersen, Lene Hoimark, Lisbeth Uhrskov Sørensen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
QTC PROLONGATION
Adult Male medicine.medical_specialty congenital hereditary and neonatal diseases and abnormalities plasma concentration Pilot Projects Sudden death 03 medical and health sciences Young Adult 0302 clinical medicine Risk Factors Internal medicine medicine Humans Antipsychotics cardiovascular diseases Psychiatry business.industry Middle Aged 030227 psychiatry Psychiatry and Mental health Long QT Syndrome Increased risk Cross-Sectional Studies Plasma concentration Qtc interval prolongation Cardiology Schizophrenia cardiovascular system Female business QTc prolongation 030217 neurology & neurosurgery Antipsychotic Agents circulatory and respiratory physiology |
| Zdroj: | Høimark, L, Uhrskov Sørensen, L & Vukelic Andersen, L 2020, ' Plasma concentrations of antipsychotics and QTc prolongation : a pilot study ', Nordic Journal of Psychiatry, vol. 74, no. 5, pp. 374-379 . https://doi.org/10.1080/08039488.2020.1729857 |
| DOI: | 10.1080/08039488.2020.1729857 |
| Popis: | Background: Certain antipsychotics are known to cause QTc interval prolongation, which has been associated with increased risk of arrhythmia and sudden death. Previous studies have investigated whether there is an association between oral antipsychotic dose and QTc interval prolongation, however only few have examined the association between antipsychotic plasma concentrations and QTc interval. Material and methods: We performed a cross-sectional study with 22 forensic psychiatric in-patients. We measured the plasma concentration of the prescribed antipsychotics and performed an ECG simultaneously. We used Bazett's formula to calculate QTc and defined QTc as prolonged when: >460 ms for women and >450 ms for men. Results: Seventy-seven percent (n = 17) of the subjects were men (mean age = 40 years) and 91% (n = 20) were diagnosed with schizophrenia. QTc’s ranged from 369 to 437 ms. Patients receiving QTc prolonging drugs had significantly greater QTc interval compared to patients receiving non-prolonging drugs. Weak to moderate negative correlations were found between QTc interval and both defined daily dose (DDD) and antipsychotic plasma concentration. There was no statistical difference between the correlations for DDD and plasma concentration versus QTc interval. Conclusion: We did not find a stronger association between antipsychotic plasma concentration and QTc than between antipsychotic dose and QTc. We suggest close monitoring with regular electroencephalogram’s until the development of a better marker for predicting the risk of cardiac arrhythmia. |
| Databáze: | OpenAIRE |
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