Procalcitonin and albumin as prognostic biomarkers in elderly patients with a risk of bacterial infection
| Autor: | Ryusho Sangen, Toshihiro Higashikawa, Yuji Kasamaki, Shigeto Morimoto, Hitoshi Saito, Masashi Okuro, Takurou Mizuno, Daisuke Usuda, Atushi Saito, Kunihiro Mae, Keiichirou Ishigami, Tsugiyasu Kanda, Akihiro Fukuda |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Prognostic factor Medicine (General) congenital hereditary and neonatal diseases and abnormalities Hospitalized patients Clinical Research Reports Biochemistry Gastroenterology Procalcitonin survival analysis 03 medical and health sciences 0302 clinical medicine R5-920 Internal medicine parasitic diseases medicine Elderly people Humans 030212 general & internal medicine Survival rate Serum Albumin albumin Aged Aged 80 and over business.industry Biochemistry (medical) Significant difference Albumin Age Factors bacterial infection Mean age Cell Biology General Medicine Bacterial Infections Middle Aged bacterial infections and mycoses Prognosis elderly patient C-Reactive Protein 030220 oncology & carcinogenesis Female business hormones hormone substitutes and hormone antagonists Biomarkers |
| Zdroj: | The Journal of International Medical Research Journal of International Medical Research, Vol 46 (2018) |
| ISSN: | 1473-2300 |
| Popis: | Aim This study was performed to investigate serum procalcitonin (PCT) and albumin (Alb) as prognostic biomarkers in elderly patients at risk of bacterial infection. Methods Serum PCT was measured in 270 hospitalized patients (mean age, 77.4 years) with suspected bacterial infection. The PCT-negative (Results C-reactive protein (CRP) was the only independent variable significantly associated with PCT positivity/negativity. In the survival analysis, the 30-day in-hospital death rate was significantly higher in the PCT-positive than -negative group. Within the Alb-positive group (>2.5 g/dL), no significant difference in survival was observed between the PCT-positive and -negative groups. However, within the Alb-negative group (≤2.5 g/dL), the survival rate was significantly lower in the PCT-positive than -negative group. PCT was strongly associated with CRP and Alb, and having both PCT positivity and Alb negativity was a prognostic factor for elderly people at risk of bacterial infection. Conclusions Combined measurement of PCT with Alb is expected to be a valuable tool to assess prognosis in elderly people at risk of bacterial infection. |
| Databáze: | OpenAIRE |
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