Validation of the PMD100 and its NOL Index to detect nociception at different infusion regimen of remifentanil in patients under general anesthesia
| Autor: | Marco Julien, Philippe Richebé, Marc Dorais, Margaret Henri, Véronique Brulotte, Madeleine Poirier, Elizabeth Décary, Rami Issa, Louis-Philippe Fortier, Pierre Drolet, Pierre-André Stöckle, Jean-François Latulippe, Olivier Verdonck |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Nociception Mean arterial pressure medicine.medical_treatment Remifentanil Anesthesia General 03 medical and health sciences 0302 clinical medicine 030202 anesthesiology Heart Rate Monitoring Intraoperative Heart rate Medicine Intubation Plethysmograph Humans Prospective Studies Infusions Intravenous Dose-Response Relationship Drug business.industry Tracheal intubation Galvanic Skin Response Middle Aged Analgesics Opioid Plethysmography Anesthesiology and Pain Medicine Bispectral index Anesthesia Female business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Minerva anestesiologica. 84(10) |
| ISSN: | 1827-1596 |
| Popis: | BACKGROUND The NOL index is based on multiparametric analysis of heart rate (HR), skin conductance, wave plethysmography, and their time derivative. The aim of this study was to evaluate the NOL to detect standardized nociceptive stimuli with various remifentanil dosages under general anesthesia. METHODS A prospective, observational study at a single center (NCT02602379) included 40 ASA I to III patients undergoing laparotomy under remifentanil-desflurane anesthesia with epidural analgesia. A tetanic stimulation was applied (forearm) at remifentanil intravenous (IV) infusion of 0.005, 0.05, 0.1, and 0.15 µg/kg/min. NOL and its variations were compared with other parameters namely heart rate, mean arterial pressure, Bispectral Index, and Analgesia Nociception Index (ANI). Receiver operating characteristic (ROC) curves were plotted to assess the response to both intubation and standardized stimulus under remifentanil infusion of 0.005 µg/kg/min. RESULTS The post-stimulation NOL values at remifentanil doses of 0.005, 0.05, 0.1 and 0.15 µg/kg/min (39 [23-55], 15 [7-30], 8 [4-14] and 8.5 [4-15]) were significantly higher than pre-stimulation counterparts (P |
| Databáze: | OpenAIRE |
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