Ethanol ingestive behavior as a function of central neurotransmission
| Autor: | Kenneth Blum, M. C. Trachtenberg, Arthur H. Briggs |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
endocrine system
medicine.medical_specialty Enkephalin Dynorphin Neurotransmission Biology Synaptic Transmission Cellular and Molecular Neuroscience Dopamine Internal medicine medicine Animals Humans Opioid peptide Molecular Biology Pharmacology Opioidergic Neurotransmitter Agents digestive oral and skin physiology Neuropeptides Brain Cell Biology medicine.disease Alcoholism Monoamine neurotransmitter Endocrinology nervous system Molecular Medicine Endorphins hormones hormone substitutes and hormone antagonists Ingestive behaviors medicine.drug |
| Zdroj: | Experientia. 45(5) |
| ISSN: | 0014-4754 |
| Popis: | Uncontrollable alcohol ingestive behavior has been linked to deficits of central neurotransmission. The pineal gland plays an important role in modulating ethanol intake in numerous animal species. The opioidergic (i.e. beta-endorphin, enkephalin, and dynorphin) system is involved in both the actions of alcohol and opiates, as well as craving and/or genetic predisposition towards abuse of these two agents. Furthermore, there is significant evidence to link ingestive behaviors with the ventral tegmental accumbens-hypothalamic axis, whereby the biogenic amines dopamine and serotonin are reciprocally involved. Evidence is presented which implicates the striatum and the hypothalamus as possible specific loci for regional differences between alcohol-preferring and alcohol-nonpreferring mice. We believe that photoperiod-induced alcohol ingestive behavior may involve alterations in both pineal and hypothalamic opioid peptides. |
| Databáze: | OpenAIRE |
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