Absolute risk estimation of new-onset proteinuria in patients with systemic lupus erythematosus – a Danish nationwide cohort study
| Autor: | Andersen, Martin, Stockmarr, Anders, Leffers, Henrik C B, Troldborg, Anne, Voss, Anne, Kristensen, Salome, Deleuran, Bent, Dreyer, Lene, Johnsen, Laura, Colic, Ada, Jacobsen, Søren |
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| Rok vydání: | 2022 |
| Zdroj: | Andersen, M, Stockmarr, A, Leffers, H C B, Troldborg, A, Voss, A, Kristensen, S, Deleuran, B, Dreyer, L, Johnsen, L, Colic, A & Jacobsen, S 2023, ' Absolute risk estimation of new-onset proteinuria in patients with systemic lupus erythematosus : a Danish nationwide cohort study ', Clinical and Experimental Rheumatology . https://doi.org/10.55563/clinexprheumatol/rk2dxp |
| DOI: | 10.21203/rs.3.rs-2064180/v1 |
| Popis: | Background Kidney involvement in systemic lupus erythematosus (SLE) affects approximately 40% of patients and is associated with increased mortality and morbidity. The risk of renal involvement has primarily been reported as hazard ratios (HR) which may be challenging to interpret on a patient level. Additional data reporting such as absolute risk estimates may strengthen risk stratification and compliance. This study provides absolute risk estimations of risk of new-onset proteinuria among SLE patients. Methods Danish SLE-centres provided clinical data on first time observations of proteinuria and other clinical parameters listed in the 1997 American College of Rheumatology Classification Criteria for SLE. Time from first occurring non-renal manifestation to new-onset proteinuria or censoring defined time at risk. Cox-regression models were used to identify risk factors for new-onset proteinuria and to calculate risk of proteinuria stratified by risk factor debut age, duration and sex. Models were reduced using a backwards elimination process for p>0.01. Potentially relevant interaction covariate terms were added to the model in a forward selection procedure using p |
| Databáze: | OpenAIRE |
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