Reproductive Benefit of Oxidative Damage: An Oxidative Stress 'Malevolence'?
| Autor: | I. Ostan, Irina Milisav, Borut Poljšak, T. Lampe |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Aging
Reactive oxygen species metabolism media_common.quotation_subject Longevity Oxidative phosphorylation Review Article Biology medicine.disease_cause Biochemistry Antioxidants Oxidative damage Molecular level medicine lcsh:QH573-671 media_common Genetics chemistry.chemical_classification Reactive oxygen species Ecology lcsh:Cytology Cell Biology General Medicine Oxidative Stress chemistry Mutation Adaptation Reactive Oxygen Species Oxidative stress Signal Transduction |
| Zdroj: | Oxidative Medicine and Cellular Longevity, Vol 2011 (2011) Oxidative Medicine and Cellular Longevity |
| ISSN: | 1942-0994 1942-0900 |
| Popis: | High levels of reactive oxygen species (ROS) compared to antioxidant defenses are considered to play a major role in diverse chronic age-related diseases and aging. Here we present an attempt to synthesize information about proximate oxidative processes in aging (relevant to free radical or oxidative damage hypotheses of aging) with an evolutionary scenario (credited here to Dawkins hypotheses) involving tradeoffs between the costs and benefits of oxidative stress to reproducing organisms. Oxidative stress may be considered a biological imperfection; therefore, the Dawkins' theory of imperfect adaptation of beings to environment was applied to the role of oxidative stress in processes like famine and infectious diseases and their consequences at the molecular level such as mutations and cell signaling. Arguments are presented that oxidative damage is not necessarily an evolutionary mistake but may be beneficial for reproduction; this may prevail over its harmfulness to health and longevity in evolution. Thus, Dawkins' principle of biological “malevolence” may be an additional biological paradigm for explaining the consequences of oxidative stress. |
| Databáze: | OpenAIRE |
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