Prevalence and risk profile of retinopathy in non‐diabetic subjects: National Health and Nutrition Examination Survey 2005 to 2008

Autor:	Jian Zhang, Wei Wang, Zhuoting Zhu, Mingguang He, Jane Scheetz
Rok vydání:	2019
Předmět:	Adult Blood Glucose Male medicine.medical_specialty National Health and Nutrition Examination Survey Cross-sectional study Population Risk Factors Diabetes mellitus Internal medicine Prevalence Humans Medicine education Glycated Hemoglobin education.field_of_study Diabetic Retinopathy business.industry Diabetic retinopathy Odds ratio Middle Aged Nutrition Surveys medicine.disease United States Confidence interval Ophthalmology Cross-Sectional Studies Female business Biomarkers Retinopathy
Zdroj:	Clinical & Experimental Ophthalmology. 47:1173-1181
ISSN:	1442-9071 1442-6404
DOI:	10.1111/ceo.13595
Popis:	Importance Recent US national population-based data on the prevalence of retinopathy in non-diabetic participants is limited. Background To assess the prevalence and risk factors of retinopathy in a representative US population without diabetes. Design Population-based, cross-sectional study. Participants A total of 4354 non-diabetic participants 40 years and older with valid fundus photographs in the 2005 to 2008 National Health and Nutrition Examination Survey. Methods Diabetes mellitus was defined as glycosylated haemoglobin (HbA1c) ≥6.5%, physician diagnosis of diabetes mellitus or use of diabetic medication. Retinopathy level was based on the Modified Airlie House adaptation from the Early Treatment Diabetic Retinopathy Study (ETDRS) protocol. Risk profile was assessed from standardized interviews, clinical examinations and laboratory measurements. Main outcome measures Prevalence and risk profile of retinopathy in non-diabetic participants. Results The overall weighted prevalence of retinopathy was 6.7% (n = 341). Among them, 98.2% (n = 331) had signs of minimal-to-mild non-proliferative retinopathy (ETDRS level 14-31) while only 1.8% (n = 10) had moderate-to-severe non-proliferative retinopathy (ETDRS level 41-51). After adjusting for multiple covariates, retinopathy signs in non-diabetic participants were associated with male gender (odds ratio [OR] 1.54; 95% confidence interval [CI] 1.22-1.93), systolic blood pressure (OR per 10 mmHg increase 1.11; 95% CI 1.03-1.19), HbA1c (OR per % increase 1.43; 95% CI 1.01-2.05) and history of stroke (OR 2.39; 95% CI 1.14-5.04). Conclusions and relevance Consistent with previous studies, signs of retinopathy are common in US persons without diabetes. Risk factors for retinopathy signs include gender, blood pressure, HbA1c and history of stroke.
Databáze:	OpenAIRE
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