Chromosomal aberrations in lymphocytes of peripheral blood among Mayak facility workers who inhaled insoluble forms of 239PU
| Autor: | V. A. Syrchikov, Z B Tokarskaya, N D Okladnikova, Bobby R. Scott, G. V. Zhuntova, E. S. Grigoryeva, V. F. Khokhryakov |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male First contact medicine.medical_specialty Alpha (ethology) Nuclear Reactors Occupational Exposure Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Lymphocytes Chromosome Aberrations Radiation Radiological and Ultrasound Technology Inhalation business.industry Chemistry Public Health Environmental and Occupational Health Gamma ray Dose-Response Relationship Radiation Total body General Medicine Alpha particle Alpha Particles Plutonium Peripheral blood Endocrinology Gamma Rays Peripheral blood lymphocyte Cytogenetic Analysis Body Burden Female Nuclear medicine business |
| Zdroj: | Radiation Protection Dosimetry. 113:3-13 |
| ISSN: | 1742-3406 0144-8420 |
| DOI: | 10.1093/rpd/nch417 |
| Popis: | A cytogenetic study was performed on 79 plutonium (Pu) workers chronically exposed to alpha radiation from inhaled, low-transportable (insoluble) compounds of airborne 239Pu and to external gamma rays. Body burden estimates for 239Pu ranged from 0 to 15.5 kBq. Chromosomal aberrations (CAs) (stable and unstable) among peripheral blood lymphocytes and cumulative alpha radiation doses were evaluated approximately 25 y after first contact with 239Pu. For the cytogenetic analyses, a standard two-day peripheral blood lymphocyte culture technique was applied. While alpha radiation doses continually increase up to the time of cytogenetic measurements, significant gamma ray exposures essentially ceased long before the time of measurement, so that alpha and gamma doses were not correlated. For the exposed workers, the mean 239Pu body burden (estimate), evaluated at the time of the cytogenetic measurement, was 1.23 +/- 0.26 kBq and the corresponding mean absorbed external gamma ray dose (estimate) to the total body was 0.076 +/- 0.009 Gy. Single and multivariate regression analyses were performed on the CA data. Stable, unstable and total aberrations increased as the 239Pu body burden increased over the range 0-4.5 kBq. However, above this range little additional increase was observed. CAs were weakly correlated with time since the first intake of 239Pu. No relationship between chromatid aberrations and 239Pu incorporation was found. Unstable (but not stable) aberrations were correlated with gamma radiation dose. No significant relationship of CA and smoking was found. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|