Evaluation of Hyaluronic Acid Dilutions at Different Concentrations Using a Quartz Crystal Resonator (QCR) for the Potential Diagnosis of Arthritic Diseases
| Autor: | Oscar Leonardo Herrera Sandoval, Luis Armando Carvajal Ahumada, Marco Xavier Rivera González, José Javier Serrano Olmedo |
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| Rok vydání: | 2016 |
| Předmět: |
Serial dilution
Medicina Rheometer 02 engineering and technology non-Newtonian fluid lcsh:Chemical technology 01 natural sciences Biochemistry Viscoelasticity Article Analytical Chemistry Viscosity chemistry.chemical_compound synovial fluid Hyaluronic acid Synovial fluid Humans lcsh:TP1-1185 Electrical and Electronic Engineering Hyaluronic Acid arthritic disease Instrumentation Chromatography Chemistry Arthritis 010401 analytical chemistry Viscometer viscosity QCR 021001 nanoscience & nanotechnology Atomic and Molecular Physics and Optics Non-Newtonian fluid 0104 chemical sciences Immunology 0210 nano-technology |
| Zdroj: | Sensors (Basel, Switzerland) Sensors, Vol 16, Iss 11, p 1959 (2016) Sensors, ISSN 1424-8220, 2016-11, Vol. 16, No. 11 Archivo Digital UPM Universidad Politécnica de Madrid Sensors; Volume 16; Issue 11; Pages: 1959 |
| ISSN: | 1424-8220 |
| Popis: | The main objective of this article is to demonstrate through experimental means the capacity of the quartz crystal resonator (QCR) to characterize biological samples of aqueous dilutions of hyaluronic acid according to their viscosity and how this capacity may be useful in the potential diagnosis of arthritic diseases. The synovial fluid is viscous due to the presence of hyaluronic acid, synthesized by synovial lining cells (type B), and secreted into the synovial fluid thus making the fluid viscous. In consequence, aqueous dilutions of hyaluronic acid may be used as samples to emulate the synovial fluid. Due to the viscoelastic and pseudo-plastic behavior of hyaluronic acid, it is necessary to use the Rouse model in order to obtain viscosity values comparable with viscometer measures. A Fungilab viscometer (rheometer) was used to obtain reference measures of the viscosity in each sample in order to compare them with the QCR prototype measures. |
| Databáze: | OpenAIRE |
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