Physiological Responses of Rats Fed Loline and Ergot Alkaloids from Endophyte-Infected Tall Fescue
| Autor: | R.W. Hemken, J.A. Jackson, Lowell P. Bush, Malcolm R. Siegel, R. J. Petroski, R. G. Powell, Panayiotis M. Zavos, D.R. Varney |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
Ergot Alkaloids endocrine system Food intake Chromatography Gas Health Toxicology and Mutagenesis Negative control Poaceae Weight Gain Toxicology complex mixtures Endophyte Rats Sprague-Dawley Random Allocation Alkaloids Animal science Feeding behavior Botany Sprague dawley rats Animals Testosterone heterocyclic compounds Pyrrolizidine Alkaloids Pharmacology Chemical Health and Safety biology organic chemicals Alkaloid Public Health Environmental and Occupational Health Mycotoxicosis Organ Size General Medicine Alkaline Phosphatase biology.organism_classification Animal Feed Physiological responses Prolactin Rats Acremonium Biological Assay Festuca arundinacea |
| Zdroj: | Drug and Chemical Toxicology. 19:85-96 |
| ISSN: | 1525-6014 0148-0545 |
| Popis: | Sixty-three male sprague Dawley rats were randomly assigned to dietary treatments containing 1) N-formylloline alkaloid (NFL), 2) N-acetylloline alkaloid (NAL), 3) NFL + NAL, 4) NFL + a mixture of ergot alkaloids, 5) NAL + a mixture of ergot alkaloids, 6) NFL + NAL + a mixture of ergot alkaloids, 7) a mixture of ergot alkaloids, 8) endophyte-free tall fescue seed (EFTF), and 9) endophyte-infected tall fescue (EITF) seed (negative control). All diets were prepared by mixing the prepared treatments and Laboratory Chow (1:1 ratio) and were fed at a maximum of 15 g per rat per day. All rats were killed at termination (d 18). Rats fed the EITF consumed less (P.05) than those fed all other treatments. Feed intake for rats fed the NFL + ergot alkaloids was lower than for those fed NAL, NAL + ergot alkaloids, NFL + NAL + ergot alkaloids, ergot alkaloids, and EFTF treatments. Average daily weight gains (ADG) followed a trend similar to feed intake with some exceptions. Rats fed the NFL + NAL treatments had higher (P.05) ADG than those fed all other treatments except the NFL + NAL + ergot alkaloid treatment. Rats fed the EITF had lower (P.05) ADG than those fed all other treatments except those fed ergot alkaloids and NAL + ergot alkaloids. Epididymides, testes, hypothalamus, corpus striatum weights, prolactin and alkaline phosphatase content were not altered by dietary treatments. Results suggest that loline alkaloids may have a slight depressing effect on feed intake. |
| Databáze: | OpenAIRE |
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