Immediate and short-term effects of pulmonary artery banding on left ventricular performance in foetal sheep
| Autor: | Teyssier G, Jean-Claude Fouron, Claude Chartrand, Amanda Skoll, Sven-Erik Sonesson |
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| Rok vydání: | 2004 |
| Předmět: |
Time Factors
Doppler echocardiography Pulmonary Artery Ventricular Function Left Pulmonary artery banding Fetal Heart Afterload Heart Rate medicine.artery Medicine Animals Postoperative Period Analysis of Variance Sheep medicine.diagnostic_test business.industry Stroke Volume General Medicine Stroke volume Left pulmonary artery Echocardiography Doppler Preload medicine.anatomical_structure Ventricle Anesthesia Pediatrics Perinatology and Child Health Pulmonary artery business Vascular Surgical Procedures |
| Zdroj: | Acta paediatrica (Oslo, Norway : 1992). 93(4) |
| ISSN: | 0803-5253 |
| Popis: | Aim: To evaluate foetal left ventricular performance when its preload was increased by banding the pulmonary artery, a study design where a simultaneous change in left ventricular afterload is unlikely. Methods: Nine ovine foetuses were studied with real-time images and Doppler echocardiography before, 3–4 and 6–8 d after surgery. Seven of these foetuses were also studied during the surgical intervention, immediately before and within 2 min after banding. Results: The immediate effects of a 90-95% reduction of the pulmonary artery cross-sectional area were: a 53 ±; 20% (mean ±; SD) decrease and a 38 ±; 10% increase of right (RvQ) and left ventricular output (LvQ), respectively. Comparing measurements before and 3–4 d after operation, there was a 64 ±; 16% decrease of RvQ and a 64 ±; 25% increase of LvQ. The increase in LvQ was due to an increase in both heart rate (19 ±; 10%) and stroke volume (38 ±; 18%). After an additional 3–4 postoperative days, heart rate remained increased to the same extent, but there was a more pronounced increase of LvQ (93 ±; 19%) and stroke volume (59 ±; 22%). Conclusion: The parallel foetal circulation has a capacity to handle a severely increased afterload for the right ventricle by immediately improving and maintaining an increased left ventricular performance. This improvement was in part accomplished by an increase in stroke volume. |
| Databáze: | OpenAIRE |
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