Effect of combined nitric oxide inhalation and N sup G-nitro-L-arginine infusion in porcine endotoxin shock
| Autor: | Anders Rudehill, Eddie Weitzberg, Jan M. Lundberg, Agnes Modin |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Arginine Swine Drug Evaluation Preclinical Nitric Oxide Critical Care and Intensive Care Medicine Nitroarginine Nitric oxide chemistry.chemical_compound Internal medicine Administration Inhalation medicine Animals Neuropeptide Y Infusions Intravenous Escherichia coli Infections Inhalation business.industry Endothelins medicine.disease Shock Septic Pulmonary hypertension Specific Pathogen-Free Organisms medicine.anatomical_structure Blood pressure Endocrinology chemistry Shock (circulatory) Anesthesia Vascular resistance Drug Therapy Combination Female medicine.symptom business |
| Zdroj: | Critical Care Medicine. 23:909-918 |
| ISSN: | 0090-3493 |
| DOI: | 10.1097/00003246-199505000-00020 |
| Popis: | Objective: To evaluate the possible effects of a combination of systemic nitric oxide synthesis inhibition (to increase mean arterial blood pressure) and nitric oxide inhalation (to decrease pulmonary vascular pressure) in porcine endotoxin shock. Design: Prospective trial. Setting: Laboratory at a large University medical center. Subjects: Ten pathogen-free pigs weighing 19 to 25 kg. Interventions: After surgical preparation, all pigs received a continuous infusion of Escherichia coli lipopolysaccharide endotoxin (15 μg/kg/hr) for 2 hrs. After 1 hr of endotoxemia, nitric oxide inhalation (50 parts per million) and N G -nitro-L-arginine infusion (50 mg/kg/hr) were initiated in six pigs. Four pigs served as controls and received only a lipopolysaccharide infusion. Measurements and Main Results: N G -nitro-L-arginine infusion and nitric oxide inhalation prevented the further decrease in mean arterial blood pressure seen in the control pigs (p |
| Databáze: | OpenAIRE |
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