In vivo microdialysis of amino acid neurotransmitters in the hippocampus in amygdaloid kindled rat
| Autor: | Hideki Matsui, Osamu Hatase, Tetsuro Negi, Kiyoshi Hosokawa, Yuichiro Minamoto, Najma A. Janjua, Masaaki Tokuda, Yasushi Okada, Toshifumi Itano, Tetuhide H. Murakami |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Microdialysis Time Factors Hippocampus Glutamic Acid Biology Epilepsy Glutamates In vivo Reference Values Internal medicine medicine Extracellular Kindling Neurologic Animals Molecular Biology Chromatography High Pressure Liquid gamma-Aminobutyric Acid chemistry.chemical_classification Aspartic Acid Kindling General Neuroscience Glutamate receptor Rats Inbred Strains medicine.disease Amygdala Electric Stimulation Amino acid Rats Endocrinology nervous system Biochemistry chemistry Neurology (clinical) Dialysis Developmental Biology |
| Zdroj: | Brain research. 573(2) |
| ISSN: | 0006-8993 |
| Popis: | Extracellular concentrations of γ-aminobutyric acid (GABA), glutamate (Glu) and aspartate (Asp) were determined by microdialysis in rat hippocampus during various amygdaloid kindled stages. The values of GABA and Glu were increased 3–4 times in C2–C3 stages in comparison with the values in control animals. After reaching the C5 stage, these values were increased 3–7 times. However, the concentration of Asp decreased depending on the kindling stage, reaching the lowest value of 33% in comparison with the normal value. The observed changes may be related to kindling induced seizures. |
| Databáze: | OpenAIRE |
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