Predisposing Gene for Early-Onset Prostate Cancer, Localized on Chromosome 1q42.2-43
| Autor: | Philippe Mangin, Eric Drelon, Antoine Valeri, Pierre Teillac, Annick Cohen-Akenine, Georges Fournier, Imène Mellah, Rosette Lidereau, Christine Bellané-Chantelot, Hélène Blanché, Philippe Berthon, Olivier Cussenot, Robert de Petriconi, Philippe Millasseau, Alain Latil, Florence Demenais, Lucien Bachner, Norman J. Maitland, Gudrun Wöhr, Nadine Cohen, Ilya Chumakov, Richard E. Hautmann, Daniel Cohen, Alain Le Duc, Thomas Paiss, Walther Vogel |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Genotype Genetic Linkage Locus (genetics) Biology Genetic determinism Familial prostate cancer Genetic Heterogeneity Chromosome 1q Prostate cancer Genetic model Genetics medicine Genetic predisposition Humans Genetics(clinical) Genetic Predisposition to Disease Cancer prostate Age of Onset Genetics (clinical) Linkage Chromosome Mapping Prostatic Neoplasms medicine.disease ELAC2 Chromosomes Human Pair 1 Lod Score Age of onset Early onset Microsatellite Repeats Research Article |
| Zdroj: | The American Journal of Human Genetics. 62:1416-1424 |
| ISSN: | 0002-9297 |
| DOI: | 10.1086/301879 |
| Popis: | SummaryThere is genetic predisposition associated with ⩾10% of all cancer of the prostate (CaP). By means of a genomewide search on a selection of 47 French and German families, parametric and nonparametric linkage (NPL) analysis allowed identification of a locus, on chromosome 1q42.2-43, carrying a putative predisposing gene for CaP (PCaP). The primary localization was confirmed with several markers, by use of three different genetic models. We obtained a maximum two-point LOD score of 2.7 with marker D1S2785. Multipoint parametric and NPL analysis yielded maximum HLOD and NPL scores of 2.2 and 3.1, respectively, with an associated P value of .001. Homogeneity analysis with multipoint LOD scores gave an estimate of the proportion of families with linkage to this locus of 50%, with a likelihood ratio of 157/1 in favor of heterogeneity. Furthermore, the 9/47 families with early-onset CaP at age |
| Databáze: | OpenAIRE |
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