| Autor: |
Yuta Takamura, Izumi Kato, Manami Fujita-Takahashi, Midori Azuma-Nishii, Masaki Watanabe, Rui Nozaki, Masaru Akehi, Takanori Sasaki, Hiroyuki Hirano, Hiroki Kakuta |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
ACS Pharmacology & Translational Science. 5:811-818 |
| ISSN: |
2575-9108 |
| DOI: |
10.1021/acsptsci.2c00126 |
| Popis: |
Bexarotene, a retinoid X receptor (RXR) agonist, is used to treat cutaneous T-cell lymphoma, and drug repositioning research has also been reported, despite warnings of teratogenicity. However, fetal transfer of bexarotene and its effect on rat fetal bone formation have not been examined. In this study, we conducted a detailed teratogenicity and fetal transferability assessment of bexarotene in rats. Repeated administration of bexarotene during pregnancy caused marked fetal atrophy and bone dysplasia. Although fetal transfer was not detectable by dynamic imaging of [ |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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