Cerebrospinal Fluid Biomarkers in Parkinson’s Disease: A Critical Overview of the Literature and Meta-Analyses
| Autor: | Kae Takahashi, Takayuki Katayama, Osamu Yahara, Jun Sawada |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty Opinion Parkinson's disease Amyloid Disease amyloid β42 medicine.disease_cause cerebrospinal fluid lcsh:RC321-571 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid α-synuclein medicine tau Cognitive decline lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry 030304 developmental biology 0303 health sciences business.industry General Neuroscience medicine.disease Review article neurofilament light chain Tau phosphorylation Parkinson’s disease business 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Brain Sciences, Vol 10, Iss 466, p 466 (2020) Brain Sciences |
| ISSN: | 2076-3425 |
| Popis: | Parkinson’s disease (PD) is a common neurodegenerative disorder; however, well-established biochemical markers have not yet been identified. This review article covers several candidate cerebrospinal fluid (CSF) biomarkers for PD based on the recent literature and meta-analysis data. The decrease of α-synuclein in PD is supported by meta-analyses with modest reproducibility, and a decrease of amyloid β42 is seen as a prognostic marker for cognitive decline. Tau, phosphorylated tau (p-tau), and neurofilament light chains have been used to discriminate PD from other neurodegenerative disorders. This article also describes more hopeful biochemical markers, such as neurotransmitters, oxidative stress markers, and other candidate biomarkers. |
| Databáze: | OpenAIRE |
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