Male rat exposure to low dose of di(2-ethylhexyl) phthalate during pre-pubertal, pubertal and post-pubertal periods: Impact on sperm count, gonad histology and testosterone secretion
| Autor: | Henni Chader, Batoul Latreche, Bachir Bouzid, Sofiane Boudalia, Kheira Bendisari, Mokrane Iguer-Ouada, Malha Oudir |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Aging endocrine system medicine.medical_specialty Gonad Cell Count 010501 environmental sciences Toxicology 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Diethylhexyl Phthalate Internal medicine Testis medicine Animals Testosterone Sexual Maturation Rats Wistar 0105 earth and related environmental sciences Sertoli Cells Dose-Response Relationship Drug urogenital system business.industry Low dose Phthalate Leydig Cells Histology Sertoli cell Spermatozoa Sperm 030104 developmental biology medicine.anatomical_structure Endocrinology Endocrine disruptor chemistry Environmental Pollutants business |
| Zdroj: | Reproductive Toxicology. 75:33-39 |
| ISSN: | 0890-6238 |
| DOI: | 10.1016/j.reprotox.2017.11.004 |
| Popis: | Di (2-ethylhexyl) phthalate (DEHP) is the most ubiquitous endocrine disruptor in the environment. The present study aimed to investigate the low dose effects of DEHP on the male reproductive system of rats exposed during the pre-pubertal, pubertal and post-pubertal periods. Male Wistar rats were daily gavaged by DEHP from postnatal day (PND) 21 to PND 120 with 0.5, 50 and 5000 μg/kg BW/d. A decrease in sperm count of 41%, 24% and 46% was observed at 0.5, 50 and 5000 μg/kg BW/d respectively. A decrease of Sertoli cells number was observed at 50 and 5000 μg/kg BW/d (22% and 42%, respectively). Non-monotonic dose–response was observed for testosterone levels with a significant increase at 50 μg/kg BW/d associated to a notable enhancement of Leydig cells number (35%). In conclusion, our results showed that postnatal exposure to low doses of DEHP affects sperm count, Sertoli and Leydig cells number and testosterone level. |
| Databáze: | OpenAIRE |
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