Arterial and venous blood sampling is equally applicable for coagulation and fibrinolysis analyses
| Autor: | Silje Hovden Christensen, Peter Henrik Nissen, Niels Eykens Hjørnet, Jacob Raben Greisen, Anne-Mette Hvas |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Fibrin
Fibrinolysis Biochemistry (medical) Clinical Biochemistry Thrombin Fibrinogen blood coagulation tests General Medicine Antithrombins Thrombelastography Cohort Studies Phlebotomy platelet function tests hemostasis Humans Partial Thromboplastin Time Blood Coagulation Tests fibrin clot lysis time |
| Zdroj: | Christensen, S H, Nissen, P H, Hjørnet, N E, Greisen, J R & Hvas, A M 2022, ' Arterial and venous blood sampling is equally applicable for coagulation and fibrinolysis analyses ', Clinical Chemistry and Laboratory Medicine, vol. 60, no. 11, pp. 1847-1854 . https://doi.org/10.1515/cclm-2022-0567 |
| DOI: | 10.1515/cclm-2022-0567 |
| Popis: | Objectives No consensus exists upon whether arterial and venous blood samples are equivalent when it comes to coagulation analyses. We therefore conducted a comparative cohort study to clarify if arteriovenous differences affect analyses of primary and secondary hemostasis as well as fibrinolysis. Methods Simultaneous paired blood samplings were obtained from a cannula in the radial artery and an antecubital venipuncture in 100 patients immediately before or one day after thoracic surgery. Analyses of platelet count and aggregation, International Normalized Ratio (INR), activated partial thromboplastin time (APTT), antithrombin, thrombin time, fibrinogen, D-dimer, rotational thromboelastometry (ROTEM), thrombin generation, prothrombin fragment 1 + 2, and an in-house dynamic fibrin clot formation and lysis assay were performed. Results No differences were found between arterial and venous samples for the far majority of parameters. The only differences were found in INR, median (IQR): venous, 1.1 (0.2) vs. arterial, 1.1 (0.2) (p Conclusions The sampling site does not affect the majority of coagulation analyses. Small differences were found for two parameters. Due to numerically very discrete differences, they are of no clinical relevance. In conclusion, the present data suggest that both samples obtained from arterial and venous blood may be applied for analyses of coagulation and fibrinolysis. |
| Databáze: | OpenAIRE |
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