Smartphone‐based long‐term delayed memory performance is associated with the Preclinical Alzheimer's Cognitive Composite and CSF levels of β‐amyloid
| Autor: | Fredrik Öhman, David Berron, Johan Skoog, Timothy Hadarsson Bodin, Silke Kern, Anna Zettergren, Kathryn V. Papp, Henrik Zetterberg, Kaj Blennow, Ingmar Skoog, Michael Schöll |
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| Rok vydání: | 2022 |
| Předmět: |
Amyloid beta-Peptides
Epidemiology Health Policy Repression Psychology tau Proteins Peptide Fragments Psychiatry and Mental health Cellular and Molecular Neuroscience Cognition Developmental Neuroscience Alzheimer Disease Humans Neurogranin Cognitive Dysfunction ddc:610 Smartphone Neurology (clinical) Geriatrics and Gerontology Biomarkers Aged Retrospective Studies |
| Zdroj: | Alzheimer's and dementia 18(S2), (2022). doi:10.1002/alz.068015 Alzheimer's Association International Conference 2022 |
| ISSN: | 1552-5279 1552-5260 |
| Popis: | Remote and unsupervised cognitive testing using smartphones may improve sensitivity to detect preclinical Alzheimer’s disease (AD). In particular, cognitive testing at-home enables the evaluation of the potentially more sensitive long-term delayed memory retrieval, which is commonly not feasible in a clinical setting.MethodHere, we investigated the association between remote and unsupervised smartphone-based cognitive assessments and in-clinic cognitive measurement in older participants (CDR = 0, MMSE = 29.2, age = 77). The sample (non-demented at age 70) was derived from the Swedish population-based Gothenburg H70 Birth Cohort Studies. In a subsample of participants, the retrospective correlation with cerebrospinal fluid (CSF) biomarkers analyzed at age 70 was further explored. To this point, 177 H70-participants have consented and were enrolled into the smartphone sub-study. They completed an “Object-in-Room Recall Test“ (ORR) remotely and unsupervised using own mobile devices, and the recall session was initiated 24 hours after the initial learning phase. Available previously assessed CSF measures included the Aβ42/Aβ40-ratio, t-tau, p-tau, neurofilament light (NFL), and neurogranin, available in-clinic cognitive tests included the Rey Auditory Verbal Learning Test (RAVLT), Semantic Fluency, Digit-Symbol-Coding, and Mini Mental State Examination. The above-mentioned cognitive tests were used to derive the Preclinical Alzheimer's Cognitive Composite (PACC5), a composite designed to be sensitive to cognitive change in preclinical AD. All associations were examined using Pearson correlation coefficient.ResultPreliminary analyses in a subset of participants yielded relatively strong positive correlations between PACC5 (R = .50, p |
| Databáze: | OpenAIRE |
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