Fatty acid content and composition of phospholipids bound to the hepatic endoplasmic reticulum of the rat: Effect of pregnancy
| Autor: | G. Feuer, C.F. Feuer, M.S.I. Dhami, F.A. de la Iglesia |
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| Rok vydání: | 1979 |
| Předmět: |
Time Factors
Phospholipid Endoplasmic Reticulum Toxicology chemistry.chemical_compound Ethanolamine Pregnancy Phosphatidylcholine Animals Phospholipids Pharmacology chemistry.chemical_classification Chemistry Endoplasmic reticulum Fatty Acids Fatty acid Rats Enzyme Liver Biochemistry Docosahexaenoic acid Microsomes Liver Phosphatidylcholines Pregnancy Animal Female lipids (amino acids peptides and proteins) sense organs Polyunsaturated fatty acid |
| Zdroj: | Toxicology and Applied Pharmacology. 51:167-176 |
| ISSN: | 0041-008X |
| DOI: | 10.1016/0041-008x(79)90019-x |
| Popis: | Phospholipid and fatty acid content were decreased and fatty acid composition of hepatic microsomes was altered in the rat during pregnancy. These changes were reversible 2 to 3 weeks after parturition. Pregnancy-related fatty acid changes were mainly localized in phosphatidylcholine and -ethanolamine fractions. Both saturated and unsaturated fatty acids were altered, but the reduction of the unsaturated fraction was more pronounced. Saturated acyl components, such as palmitic, stearic, and lignoceric acids, and unsaturated ones, including palmitoleic, oleic, linoleic, eicosatrienoic, arachidonic, and eicosapentaenoic acids, were significantly decreased, whereas only docosahexaenoic acid was elevated. Fatty acid changes were greater in the unsaturated components in phosphatidylcholine and -ethanolamine fractions. The largest reduction was in palmitic, palmitoleic, stearic, oleic, linoleic, arachidonic, and eicosahexaenoic acid content. Pregnancy-related changes in fatty acid distribution and content, and in phospholipid fractions reflect a modified organization and disposition of the hepatic endoplasmic reticulum membranes. These membrane changes represent essentially topographical factors influencing the function and enzymatic activity of these membranes. |
| Databáze: | OpenAIRE |
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