Divergent synthetic approach to 6'-modified α-GalCer analogues

Autor:	Esther Dawen Yu, Serge Van Calenbergh, Dirk Elewaut, Gerd Vanhoenacker, Bruno Linclau, Koen Sandra, Dirk M. Zajonc, Nora Pauwels, Sandrine Aspeslagh
Přispěvatelé:	Medical Oncology
Jazyk:	angličtina
Rok vydání:	2011
Předmět:	mice Stereochemistry Molecular Conformation Stereoisomerism Galactosylceramides Biochemistry Article chemistry.chemical_compound Glycolipid Cytokines metabolism Galacturonic acid Animals Physical and Theoretical Chemistry Sphingosine Chemistry Hexuronic Acids Organic Chemistry Cytokines/metabolism Hexuronic Acids/administration & dosage Galactosylceramides/administration & dosage Rhamnogalacturonan I Cytokines Galactosyl ceramide surface plasmon resonance
Popis:	A synthetic approach is presented for the synthesis of galacturonic acid and D-fucosyl modified KRN7000. The approach allows for late-stage functionalisation of both the sugar 6′′-OH and the sphingosine amino groups, which enables convenient synthesis of promising 6′′-modified KRN7000 analogues.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ef48fcff5f6c82f8afdbafbd110624 https://hdl.handle.net/20.500.14017/34c61581-26d6-4670-bc4d-6bddfea16255 Zobrazit plný text záznamu