Revisiting the validity of the mouse tail suspension test: Systematic review and meta-analysis of the effects of prototypic antidepressants
| Autor: | Yelena, Stukalin, Anat, Lan, Haim, Einat |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Behavior Animal Cognitive Neuroscience Reproducibility of Results Antidepressive Agents Disease Models Animal Immobilization Mice 03 medical and health sciences Behavioral Neuroscience 030104 developmental biology 0302 clinical medicine Neuropsychology and Physiological Psychology Hindlimb Suspension Animals 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience & Biobehavioral Reviews. 112:39-47 |
| ISSN: | 0149-7634 |
| DOI: | 10.1016/j.neubiorev.2020.01.034 |
| Popis: | Animal models in neuropsychiatric research need validation. One way to address external validity is systematic reviews and meta-analyses. The present study presents a meta-analysis of the effects of antidepressants in the mouse tail suspension test (TST). A PubMed search identified studies that examined imipramine and fluoxetine effects in the TST. Inclusion criteria were testing in the light phase; trial duration was six minutes; immobility time scored 6 or (last) 4 min; adult mice; acute intraperitoneal (IP) administration. Effect sizes (ES) were estimated using Cohen's d, heterogeneity of ES with Cochran's Q test, correlations between dose and ES with Pearson's correlation and differences between strains with Analysis of variance. Results show that antidepressants decrease immobility time in the TST and a correlation between drug dose and ES but no effects of strain. We suggest that the TST is a valid tool to quantitatively, consistently and reproducibly capture the immobility-reducing aspects of fluoxetine and imipramine and that the lack of strain effects is due to small number of experiments in many of the strains. |
| Databáze: | OpenAIRE |
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