Sudden Death and an Extra-Adrenal Paraganglioma
| Autor: | Christopher M. Milroy, Jacqueline L. Parai |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Forensic pathology
medicine.medical_specialty Creatinine Case of the Month business.industry Extra-Adrenal Paraganglioma Autopsy 030204 cardiovascular system & hematology Normetanephrine medicine.disease Gastroenterology Sudden death Pathology and Forensic Medicine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Paraganglioma Internal medicine medicine 030216 legal & forensic medicine business Metanephrine |
| Zdroj: | Academic Forensic Pathology. 6:325-330 |
| ISSN: | 1925-3621 |
| DOI: | 10.23907/2016.033 |
| Popis: | Pheochromocytomas and paragangliomas are a rare cause of sudden death. We present the case of a 34-year-old male who died suddenly. He had been diagnosed as having diabetes mellitus five days previously and was hypertensive. At autopsy he had a 3.5 cm extra-adrenal mass. Histology of the tumor showed it to be a paraganglioma with the characteristic histological appearance. Postmortem biochemistry revealed a vitreous glucose of 5.9 mmol/L (106 mg/dL) with negative ketones. Urinary catecholamines were measured and revealed raised metanephrine:creatinine and normetanephrine:creatinine ratios. There may be genetic implications in patients with pheochromocytomas and paragangliomas as they are associated with a number of hereditary syndromes. |
| Databáze: | OpenAIRE |
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