Bone Marrow Cells in Acute Lymphoblastic Leukemia Create a Proinflammatory Microenvironment Influencing Normal Hematopoietic Differentiation Fates
| Autor: | Adriana Contreras-Quiroz, Elisa Dorantes-Acosta, Eduardo Vadillo, Armando Vilchis-Ordoñez, Alfonso Reyes-López, Rosana Pelayo, Henry Quintela-Nuñez del Prado, Briceida López-Martínez, Hector Mayani, Vianney Ortiz-Navarrete, Jorge Venegas-Vázquez |
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| Rok vydání: | 2015 |
| Předmět: |
Article Subject
Interleukin-1beta Population lcsh:Medicine Bone Marrow Cells Inflammation General Biochemistry Genetics and Molecular Biology Proinflammatory cytokine Bone Marrow Tumor Microenvironment medicine Humans Progenitor cell Child education Cell Proliferation B-Lymphocytes education.field_of_study Tumor microenvironment General Immunology and Microbiology Tumor Necrosis Factor-alpha business.industry lcsh:R Granulocyte-Macrophage Colony-Stimulating Factor Cell Differentiation General Medicine Precursor Cell Lymphoblastic Leukemia-Lymphoma Hematopoietic Stem Cells Interleukin-12 Endothelial stem cell Haematopoiesis medicine.anatomical_structure Immunology Bone marrow medicine.symptom business Research Article |
| Zdroj: | BioMed Research International, Vol 2015 (2015) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| DOI: | 10.1155/2015/386165 |
| Popis: | B-cell acute lymphoblastic leukemia (B-ALL) is a serious public health problem in the pediatric population worldwide, contributing to 85% of deaths from childhood cancers. Understanding the biology of the disease is crucial for its clinical management and the development of therapeutic strategies. In line with that observed in other malignancies, chronic inflammation may contribute to a tumor microenvironment resulting in the damage of normal processes, concomitant to development and maintenance of neoplastic cells. We report here that hematopoietic cells from bone marrow B-ALL have the ability to produce proinflammatory and growth factors, including TNFα, IL-1β, IL-12, and GM-CSF that stimulate proliferation and differentiation of normal stem and progenitor cells. Our findings suggest an apparently distinct CD13+CD33+population of leukemic cells contributing to a proinflammatory microenvironment that may be detrimental to long-term normal hematopoiesis within B-ALL bone marrow. |
| Databáze: | OpenAIRE |
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