Redução do conteúdo mineral ósseo em jovens portadores de esquistossomose mansônica cirúrgica: fatores envolvidos na patogênese
| Autor: | Karina de Oliveira Andrade Marques, Karina Leal Reis de Melo, Andréa Dantas Sena, Maria Virgínia da Motta Braga, Carlos Teixeira Brandt, Fernando de Souza Almeida, Antônio Marcelo Gonçalves de Souza |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Gynecology
medicine.medical_specialty Symmers´ fibrosis business.industry Esquistossomose mansônica Histomorfometria lcsh:Surgery Hystomorphometry lcsh:RD1-811 Schistosomiasis mansoni Fibrose de Symmers Magnesium status Conteúdo mineral ósseo Bone mineral density Níveis de magnésio Medicine Bone mineral content Hepatic functional reserve Surgery Densitometria óssea business Reserva funcional hepática |
| Zdroj: | Acta Cirurgica Brasileira, Volume: 16, Issue: 1, Pages: 56-61, Published: MAR 2001 Acta Cirurgica Brasileira, Vol 16, Iss 1, Pp 56-61 (2001) Acta Cirúrgica Brasileira v.16 n.1 2001 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
| Popis: | Thirty two children and adolescents from 14 to 20 years of age, suffering from hepatosplenic schistosomiasis mansoni and bleeding esophageal varicose veins, were evaluated for bone mineral density (BMD), before undergoing medical and surgical treatment. The surgical protocol was splenectomy, autoimplantation of spleen tissue into a pouch of the major omentum and ligature of the left gastric vein. Follow up of these patients’ ranges from one to ten years with a mean of five years. The BMD was measured at the lumbar spine (L2 - L4) through the dual energy absorptionmetry X-ray (DEXA), using a LUNAR DPX-L densitometer. The degree of Symmers´ fibrosis was assessed by semiautomatic hystomorphometry. In eleven patients, the serum magnesium was measured before an intravenous overload of this ion and subsequently after eight and twenty four hours. Urine was collected 24 hours before and 24 hours after the magnesium overload. Deficiency of magnesium was considered when the uptake of this ion was greater than 40%. There was a significant trend of association between the status of bone mineral content and the Symmers´ fibrosis degree (c² = 6.606 R = 0.01017). There was also a moderate agreement between the greater fibrosis densities ( > the mean percentage) and bone mineral deficits. Although the normal bone mineral content was more found among the patients with better hepatic functional reserve, the results did not reach statistical significance. There was a marked magnesium retention (>95%) in one patient who had severe osteoporosis and a slight depletion (95%) em uma paciente que tinha osteoporose e uma retenção desse íon discretamente acima de 40% em um paciente que não apresentava déficit conteúdo mineral ósseo. Em conclusão, os pacientes incluídos nesta série mostravam um importante déficit de BMD, especialmente entre as meninas, que obtiveram melhora significativa após tratamento clínico e cirúrgico. O déficit mineral ósseo desses pacientes estava associado ao grau de fibrose de Symmers. Depleção de magnésio esteve presente em dois de onze desses pacientes. Pode-se especular que a suplementação de magnésio possa ser útil para deter a progressão do déficit do conteúdo mineral ósseo nos pacientes com reserva funcional hepática mais comprometida. |
| Databáze: | OpenAIRE |
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