The association between cardiovascular disease gene mutations and recurrent pregnancy loss in the Lebanese population
| Autor: | Hanadi El Achi, Rami Mahfouz, Sarah Abou Daya, Sahar Halabi, Sandra Damianos, Johnny Awwad |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
0301 basic medicine Abortion Habitual medicine.medical_specialty Cross-sectional study Population Apolipoprotein E3 Disease Compound heterozygosity Tertiary Care Centers Loss of heterozygosity 03 medical and health sciences Mutation Rate Pregnancy Internal medicine Recurrent miscarriage Genetics medicine Humans Genetic Predisposition to Disease Lebanon education Molecular Biology Genetic Association Studies Methylenetetrahydrofolate Reductase (NADPH2) Retrospective Studies education.field_of_study biology business.industry General Medicine medicine.disease Cross-Sectional Studies 030104 developmental biology Cardiovascular Diseases Methylenetetrahydrofolate reductase Mutation biology.protein Female Prothrombin business |
| Zdroj: | Molecular Biology Reports. 45:911-916 |
| ISSN: | 1573-4978 0301-4851 |
| Popis: | Recurrent pregnancy loss (RPL) is a problem affecting up to 5% of women of childbearing age due to many factors. Studies have shown that RPL and cardiovascular disease (CVD) may have shared risk factors. We compared the prevalence of 12 cardiovascular disease related gene mutations in patients with a history of RPL to normal controls in a major tertiary care center in Lebanon. The CVD StripAssay (ViennaLab, Austria) was used to analyze the CVD genes on 70 women with RPL history as part of the initial routine workup for recurrent miscarriage at the American University of Beirut Medical Center. The obtained results were compared with data of controls from the Lebanese population using Fisher's exact test and Chi square analysis. Two genes of the CVD panel demonstrated a strong relationship with RPL, including, MTHFR (C677T homozygosity, A1298C homozygosity, and compound heterozygosity for C677T and A1298C) and Factor II (heterozygosity for G20210A). Moreover, a protective role of positive APO-E3 isoform was observed. This study is the first in the Lebanese population in associating RPL with a large panel of CVD related genes. |
| Databáze: | OpenAIRE |
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