Cardiovascular Diseases in Obesity: What is the Role of Magnesium?
| Autor: | Gilberto Simeone Henriques, Thayanne Gabryelle Visgueira de Sousa, Mickael de Paiva Sousa, Jennifer Beatriz Silva Morais, Juliana Soares Severo, Lyandra Dias da Silva, Stéfany Rodrigues de Sousa Melo, Loanne Rocha dos Santos, Dilina do Nascimento Marreiro |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Clinical Biochemistry Adipose tissue chemistry.chemical_element 010501 environmental sciences Reductase 01 natural sciences Biochemistry Inorganic Chemistry 03 medical and health sciences Nutrient Internal medicine medicine Humans Magnesium Obesity Triglycerides Dyslipidemias 0105 earth and related environmental sciences 0303 health sciences Lipoprotein lipase business.industry 030302 biochemistry & molecular biology Biochemistry (medical) Lipid metabolism General Medicine medicine.disease Endocrinology chemistry Cardiovascular Diseases Acyltransferase lipids (amino acids peptides and proteins) business |
| Zdroj: | Biological Trace Element Research. 199:4020-4027 |
| ISSN: | 1559-0720 0163-4984 |
| Popis: | An excess of adipose tissue, a characteristic of obesity, has been associated with endocrine-metabolic alterations that contribute to dyslipidemias, which are characterized by an increase in the plasma concentrations of triacylglycerols, total cholesterol, and LDL-c along with a reduction in HDL-c. Some nutrients such as the mineral magnesium play important roles in lipid metabolism. Magnesium regulates the activity of HMG-CoA reductase, increasing the activity of lipoprotein lipase and lecithin-cholesterol acyltransferase. The objective of this review is to present important aspects about the contribution of obesity to the manifestation of cardiovascular risk, to bring the main physiological functions of magnesium, as well as the role of the nutrient in the protection against cardiovascular diseases. Studies have shown that individuals with obesity have low intracellular concentrations of magnesium, which can compromise the nutrient's physiological functions. Thus, this mineral appears to play an important role in protecting against cardiovascular diseases; however, changes in the nutrient metabolism in obesity may compromise the functions of this element. Further studies are needed to clarify this. |
| Databáze: | OpenAIRE |
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