Low rate of asymptomatic cerebral embolism and improved procedural efficiency with the novel pulmonary vein ablation catheter GOLD: results of the PRECISION GOLD trial
| Autor: | Stefan G. Spitzer, Neil C. Davidson, Marcus Wieczorek, Zoltán Csanádi, Steve Furniss, Mélèze Hocini, Lukas R.C. Dekker, J. Christoph Geller, Lucas V.A. Boersma, Stephen Murray, Yves De Greef |
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| Přispěvatelé: | Other departments, Signal Processing Systems, Biomedical Diagnostics Lab |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_treatment International Cooperation PVAC GOLD Ablation 030204 cardiovascular system & hematology Pulmonary vein 0302 clinical medicine Atrial Fibrillation 030212 general & internal medicine Prospective Studies Prospective cohort study medicine.diagnostic_test Incidence Atrial fibrillation Orvostudományok Equipment Design Middle Aged Magnetic Resonance Imaging Electrodes Implanted Europe Catheter Treatment Outcome Intracranial Embolism Pulmonary Veins Catheter Ablation Female Radiology medicine.symptom Cardiology and Cardiovascular Medicine medicine.medical_specialty Catheter ablation Klinikai orvostudományok Pulmonary vein isolation Asymptomatic 03 medical and health sciences Physiology (medical) medicine Humans Aged Platinum business.industry Asymptomatic cerebral embolism Magnetic resonance imaging medicine.disease Logistic Models Linear Models Gold Nuclear medicine business |
| Zdroj: | Europace : European pacing, arrhythmias, and cardiac electrophysiology, 18(5), 687-695. Oxford University Press Europace, 18(5), 687-695. Oxford University Press |
| ISSN: | 1099-5129 |
| Popis: | Aims This prospective, multicentre study (PRECISION GOLD) evaluated the incidence of asymptomatic cerebral embolism (ACE) after pulmonary vein isolation (PVI) using a new gold multi-electrode radiofrequency (RF) ablation catheter, pulmonary vein ablation catheter (PVAC) GOLD. Also, procedural efficiency of PVAC GOLD was compared with ERACE. The ERACE study demonstrated that a low incidence of ACE can be achieved with a platinum multi-electrode RF catheter (PVAC) combined with procedural manoeuvres to reduce emboli. Methods and results A total of 51 patients with paroxysmal atrial fibrillation (AF) (age 57 ± 9 years, CHA2DS2-VASc score 1.4 ± 1.4) underwent AF ablation with PVAC GOLD. Continuous oral anticoagulation using vitamin K antagonists, submerged catheter introduction, and heparinization (ACT ≥ 350 s prior to ablation) were applied. Cerebral magnetic resonance imaging (MRI) scans were performed within 48 h before and 16–72 h post-ablation. Cognitive function assessed by the Mini-Mental State Exam at baseline and 30 days post-ablation. New post-procedural ACE occurred in only 1 of 48 patients (2.1%) and was not detectable on MRI after 30 days. The average number of RF applications per patient to achieve PVI was lower in PRECISION GOLD (20.3 ± 10.0) than in ERACE (28.8 ± 16.1; P = 0.001). Further, PVAC GOLD ablations resulted in significantly fewer low-power ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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