Fluconazole-loaded solid lipid nanoparticles topical gel for treatment of pityriasis versicolor: formulation and clinical study

Autor: Ehab R. Bendas, Mohamed A. El-Nabarawi, Yasmina Ahmed El-Attar, Hoda A Salem, Shaimaa El-Housiny, Dalia A. Attia, Maii Atef Shams Eldeen
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
Antifungal Agents
Sonication
Chemistry
Pharmaceutical
Skin Absorption
Pharmaceutical Science
pityriasis versicolor
02 engineering and technology
Topical Gel
Administration
Cutaneous
030226 pharmacology & pharmacy
03 medical and health sciences
Colloid
Surface-Active Agents
0302 clinical medicine
Drug Delivery Systems
topical delivery
Pulmonary surfactant
Solid lipid nanoparticle
Tinea Versicolor
fluconazole
medicine
entrapment efficiency
Humans
Prospective Studies
Particle Size
Drug Carriers
Chromatography
Chemistry
lcsh:RM1-950
General Medicine
Pityriasis
clinical study
021001 nanoscience & nanotechnology
medicine.disease
Lipids
carpabol 934
body regions
solid lipid nanoparticles
lcsh:Therapeutics. Pharmacology
Poloxamer 407
Nanoparticles
0210 nano-technology
Corrigendum
Gels
Fluconazole
medicine.drug
Zdroj: Drug Delivery, Vol 25, Iss 1, Pp 78-90 (2018)
Drug Delivery
ISSN: 1521-0464
1071-7544
Popis: Solid lipid nanoparticles (SLNs) are very potential formulations for topical delivery of antifungal drugs. Hence, the purpose of this research was to formulate the well-known antifungal agent Fluconazole (FLZ)-loaded SLNs topical gel to improve its efficiency for treatment of Pityriasis Versicolor (PV). FLZ-SLNs were prepared by modified high shear homogenization and ultrasonication method using different concentration of solid lipid (Compritol 888 ATO, Precirol ATO5) and surfactant (Cremophor RH40, Poloxamer 407). The physicochemical properties and the in vitro release study for all FLZ-SLNs were investigated. Furthermore, the optimized FLZ-SLN formula was incorporated into gel using Carpobol 934. A randomized controlled clinical trial (RCT) of potential batches was carried out on 30 well diagnosed PV patients comparing to market product Candistan® 1% cream. Follow up was done for 4 weeks by clinical and KOH examinations. The results showed that FlZ-SLNs were almost spherical shape having colloidal sizes with no aggregation. The drug entrapment efficiency ranged from 55.49% to 83.04%. The zeta potential values lie between −21 and −33 mV presenting good stability. FLZ showed prolonged in vitro release from SLNs dispersion and its Carbapol gel following Higuchi order equation. Clinical studies registered significant improvement (p
Databáze: OpenAIRE
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