DNA methyltransferases and gastric cancer: insight into targeted therapy
| Autor: | Fatemeh Amjadi-Moheb, Monireh Golpour, Gholam Hossein Ashrafi, Haleh Akhavan-Niaki, Maryam Pilehchian-Langroudi, Sadegh Fattahi, Marzieh Sharifi-Pasandi, Parastesh Khodadadi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cancer Research Methyltransferase medicine.medical_treatment Single-nucleotide polymorphism Antineoplastic Agents Biology DNA methyltransferase Polymorphism Single Nucleotide Targeted therapy 03 medical and health sciences chemistry.chemical_compound Stomach Neoplasms Genetics medicine cancer Animals Humans Epigenetics DNA (Cytosine-5-)-Methyltransferases Cancer DNA Methylation medicine.disease 030104 developmental biology chemistry DNA methylation Cancer research biological DNA |
| Zdroj: | Epigenomics. 10(11) |
| ISSN: | 1750-192X 1750-1911 |
| Popis: | Gastric cancer is a major health problem worldwide occupying most frequent causes of cancer-related mortality. In addition to genetic modifications, epigenetic alterations catalyzed by DNA methyltransferases (DNMTs) are a well-characterized epigenetic hallmark in gastric cancer. The reversible nature of epigenetic alterations and central role of DNA methylation in diverse biological processes provides an opportunity for using DNMT inhibitors to enhance the efficacy of chemotherapeutics. In this review, we discussed key factors or mechanisms such as SNPs, infections and genetic modifications that trigger DNMTs level modification in gastric cancer, and their potential roles in cancer progression. Finally, we focused on how inhibitors of the DNMTs can most effectively be used for the treatment of gastric cancer with multidrug resistance. |
| Databáze: | OpenAIRE |
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