Synaptic relationships between proopiomelanocortin- and ghrelin-containing neurons in the rat arcuate nucleus
| Autor: | Seiji Shioda, Mayumi Seki, Yuri Kintaka, Michiko Yagi, Jian-Lian Guan, Haruaki Kageyama, Lihua Wang, Hiromi Okuda, Fumiko Takenoya, Yasunori Hori |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
endocrine system Pro-Opiomelanocortin Physiology Clinical Biochemistry Biology Biochemistry Synapse Cellular and Molecular Neuroscience Endocrinology Proopiomelanocortin Cellular neuroscience Arcuate nucleus medicine Animals Rats Wistar Axon Neurons digestive oral and skin physiology Arcuate Nucleus of Hypothalamus Ghrelin Rats Microscopy Electron medicine.anatomical_structure nervous system Hypothalamus Synapses biology.protein Neuron Non-spiking neuron Neuroscience hormones hormone substitutes and hormone antagonists |
| Zdroj: | Regulatory Peptides. 145:128-132 |
| ISSN: | 0167-0115 |
| DOI: | 10.1016/j.regpep.2007.09.028 |
| Popis: | Both proopiomelanocortin (POMC) and ghrelin peptides are implicated in the feeding regulation. The synaptic relationships between POMC- and ghrelin-containing neurons in the hypothalamic arcuate nucleus were studied using double-immunostaining methods at the light and electron microscope levels. Many POMC-like immunoreactive axon terminals were found to be apposed to ghrelin-like immunoreactive neurons and also to make synapses with ghrelin-like immunoreactive neuronal perikarya and dendritic processes. Most of the synapses were symmetrical in shape. A small number of synapses made by ghrelin-like immunoreactive axon terminals on POMC-like immunoreactive neurons were also identified. Both the POMC- and ghrelin-like immunoreactive neurons were found to contain large dense granular vesicles. These data suggest that the POMC-producing neurons are modulated via synaptic communication with ghrelin-containing neurons. Moreover, ghrelin-containing neurons may also have a feedback effect on POMC-containing neurons through direct synaptic contacts. |
| Databáze: | OpenAIRE |
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