Assessment of need for hemostatic evaluation in patients taking valproic acid: A retrospective cross-sectional study
| Autor: | Demi S. Post, Arian van der Veer, Olaf E. M. G. Schijns, Sylvia Klinkenberg, Kim Rijkers, G. Louis Wagner, Vivianne H. J. M. van Kranen-Mastenbroek, Paul C. P. H. Willems, Paul W. M. Verhezen, Erik A. M. Beckers, Floor C. J. I. Heubel-Moenen, Yvonne M. C. Henskens |
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| Přispěvatelé: | Kindergeneeskunde, MUMC+: MA Medische Staf Kindergeneeskunde (9), MUMC+: MA Med Staf Spec Neurochirurgie (9), RS: MHeNs - R3 - Neuroscience, Klinische Neurowetenschappen, MUMC+: MA Med Staf Spec Neurologie (9), RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, MUMC+: HZC Med Staf Spec Klinische Neurofys (9), RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, Interne Geneeskunde, MUMC+: MA Hematologie (9), RS: Carim - B01 Blood proteins & engineering, MUMC+: DA CDL Algemeen (9), RS: Carim - B04 Clinical thrombosis and Haemostasis, Central Diagnostic Lab |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Adolescent Platelet Function Tests SURGERY DISORDERS CHILDREN THERAPY Hemostatics HEMORRHAGE BLOOD-LOSS Humans Hemostatics/administration & dosage DRUG Preschool Child Aged Retrospective Studies Multidisciplinary Incidence Valproic Acid Infant Blood Coagulation Disorders Middle Aged Valproic Acid/administration & dosage Thrombocytopenia BLEEDING COMPLICATIONS Cross-Sectional Studies Child Preschool Blood Coagulation Disorders/blood Female Thrombocytopenia/blood |
| Zdroj: | PLOS ONE, 17(2):e0264351. Public Library of Science |
| ISSN: | 1932-6203 |
| Popis: | Introduction Valproic acid (VPA) is a frequently prescribed anti-epileptic drug. Since its introduction side effects on hemostasis are reported. However, studies show conflicting results, and the clinical relevance is questioned. We aimed to determine the coagulopathies induced by VPA in patients who undergo high-risk surgery. The study results warrant attention to this issue, which might contribute to reducing bleeding complications in future patients. Methods Between January 2012 and August 2020, 73 consecutive patients using VPA were retrospectively included. Extensive laboratory hemostatic assessment (including platelet function tests) was performed before elective high-risk surgery. Patient characteristics, details of VPA treatment, and laboratory results were extracted from medical records. Results 46.6% of the patients using VPA (n = 73) showed coagulopathy. Mainly, platelet function disorder was found (36.4%). Thrombocytopenia was seen in 9.6% of the patients. Data suggested that the incidence of coagulopathies was almost twice as high in children as compared to adults and hypofibrinogenemia was only demonstrated in children. No association was found between the incidence of coagulopathies and VPA dosage (mg/kg/day). Conclusion A considerable number of patients using VPA were diagnosed with coagulopathy, especially platelet function disorder. Further prospective studies are needed to confirm the need for comprehensive laboratory testing before elective high-risk surgery in these patients. |
| Databáze: | OpenAIRE |
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