| Autor: |
Meybohm, Patrick, Kohlhaas, Madeline, Boening, Andreas, Niemann, Bernd, Sander, Michael, Roesner, Jan, Kletzin, Frank, Mutlak, Haitham, Westphal, Sabine, Laufenberg-Feldmann, Rita, Ferner, Marion, Brandes, Ivo F., Stoppe, Christian, Bauer, Martin, Stehr, Sebastian N., Kortgen, Andreas, Wittmann, Maria, Baumgarten, Georg, Meyer-Treschan, Tanja, Kienbaum, Peter, Heringlake, Matthias, Schoen, Julika, Treskatsch, Sascha, Gruenewald, Matthias, Smul, Thorsten, Wolwender, Ewa, Schilling, Thomas, Fuernau, Georg, Bogatsch, Holger, Brosteanu, Oana, Hasenclever, Dirk, Zacharowski, Kai, RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study Collaborators, Stevanovic, Ana, Renner, Jochen, Rossaint, Rolf, Felzen, Marc, Goetzenich, Andreas, Moormann, Tobias, Chalk, Katharina, Knuefermann, Pascal, Recht, Thomas, Hoeft, Andreas, Winterhalter, Michael, Iken, Sonja, Bein, Berthold, Wiedenbeck, Carolin, Schwarzmann, Gerhard, Lindau, Simone, Zierer, Andreas, Fichtlscherer, Stephan, Goerlach, Gerold, Wollbrueck, Matthias, Boening, Ursula, Weigand, Markus, Strauchmann, Julia, Albrecht, Martin, Morsbach, Kai U., Paxian, Markus, Reinhard, Konrad, Scholz, Jens, Broch, Ole, Francksen, Helga, Kuhr, Bernd, Heinze, Hermann, Paarmann, Hauke, Cremer, Jochen, Sievers, Hans-Hinrich, Klotz, Stefan, Hachenberg, Thomas, Werner, Christian, Mauff, Susanne, Alms, Angela, Bergt, Stefan, Roewer, Norbert, Coburn, Mark, Schaelte, Gereon |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Journal of the American Heart Association 7(7), (2018). doi:10.1161/JAHA.117.008077
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Popis: |
Background Remote ischemic preconditioning ( RIPC ) has been suggested to protect against certain forms of organ injury after cardiac surgery. Previously, we reported the main results of RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study, a multicenter trial randomizing 1403 cardiac surgery patients receiving either RIPC or sham‐ RIPC . Methods and Results In this follow‐up paper, we present 1‐year follow‐up of the composite primary end point and its individual components (all‐cause mortality, myocardial infarction, stroke and acute renal failure), in a sub‐group of patients, intraoperative myocardial dysfunction assessed by transesophageal echocardiography and the incidence of postoperative neurocognitive dysfunction 5 to 7 days and 3 months after surgery. RIPC neither showed any beneficial effect on the 1‐year composite primary end point ( RIPC versus sham‐ RIPC 16.4% versus 16.9%) and its individual components (all‐cause mortality [3.4% versus 2.5%], myocardial infarction [7.0% versus 9.4%], stroke [2.2% versus 3.1%], acute renal failure [7.0% versus 5.7%]) nor improved intraoperative myocardial dysfunction or incidence of postoperative neurocognitive dysfunction 5 to 7 days (67 [47.5%] versus 71 [53.8%] patients) and 3 months after surgery (17 [27.9%] versus 18 [27.7%] patients), respectively. Conclusions Similar to our main study, RIPC had no effect on intraoperative myocardial dysfunction, neurocognitive function and long‐term outcome in cardiac surgery patients undergoing propofol anesthesia. Clinical Trial Registration URL: https://www.clinicaltrials.gov . Unique identifier: NCT 01067703. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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